Abraham
Jonathan Abraham
Assistant Professor of Microbiology

Abraham Lab
77 Avenue Louis Pasteur
NRB 939
Boston MA 02115
Email:jonathan_abraham@hms.harvard.edu

Website:
http://abrahamlab.med.harvard.edu/
Lab Size: Between 5-10

Summary

We use methods in molecular biology, immunology, and structural biology to study how pathogens interact with the cells of their hosts. We focus on emerging viruses that cause lethal human diseases with limited treatment or vaccine options. These include coronaviruses, filoviruses, arenaviruses, and alphaviruses.


Publications

1. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Griffiths A, Abraham J#. Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. bioRxiv, 2020.2011.2013.381533.
2. Abraham J. (2020) Passive antibody therapy in COVID-19. Nature Reviews Immunology. https://doi.org/10.1038/s41577-020-0365-7
3. Clark LE*, Mahmutovic S*, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA, Wucherpfennig KW, Paessler S, Abraham J. (2018) Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nature Communications. 9,1884.
4. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. (2018) Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. Jan; 359 (6371):48-55.
5. Mahmutovic S, Clark L, Levis SC, Briggiler AM, Enria DA, Harrison SC, Abraham J. (2015) Molecular basis for antibody-mediated neutralization of New World hemorrhagic fever mammarenaviruses. Cell Host & Microbe. 18, 1-9.