Marco Jost

Assistant Professor of Microbiology

Description

Jost Lab
4 Blackfan Circle
HIM 1042
Boston, MA 02115
Email: marco_jost@hms.harvard.edu

Website: jostlab.org
Lab Size: Between 5-10

Summary

We seek to decode the molecular language of host-microbiome communication using systematic CRISPR technologies and an interdisciplinary set of focused approaches.

Publications

Jost M*^#, Jacobson AN*, Hussmann JA, Cirolia G, Fischbach MA^#, Weissman JS^#. CRISPR-based functional genomics in human dendritic cells. eLife 2021, 10:e65856 and bioRxiv 2020, doi: 10.1101/2020.12.22.423985. * contributed equally; ^#corresponding author.

Jost M*, Santos DA*, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS. Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Nature Biotech 2020, 38, 355-364 and bioRxiv 2019, doi: 10.1101:717389. * contributed equally.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell 2017, 68, 210-223.

Adamson B*, Norman TM*, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 2016, 167, 1867-1882. * contributed equally

Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. Structural Basis for Gene Regulation by a B12-Dependent Photoreceptor. Nature 2015, 526, 536-541.