2019

2018

2017

2016

2015

2014

2013

2012

2019

  • Basu SS, Regan MS, Randall EC, Abdelmoula WM, Clark AR, Gimenez-Cassina Lopez B, Cornett DS, Haase A, Santagata S, Agar NYR. Rapid MALDI mass spectrometry imaging for surgical pathology. NPJ Precis Oncol. 2019 Jul 4;3:17. doi: 10.1038/s41698-019-0089-y. eCollection 2019. PubMed PMID: 31286061; PubMed Central PMCID: PMC6609678.
  • Basu SS, McMinn MH, Giménez-Cassina Lopéz B, Regan MS, Randall EC, Clark AR, Cox CR, Agar NYR. Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLIMSI) Using Cerium(IV) Oxide. Anal Chem. 2019 May 21;91(10):6800-6807. doi: 10.1021/acs.analchem.9b00894. Epub 2019 May 8. PubMed PMID: 31025851.
  • Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP. In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe. ACS Chem Biol. 2019 Jun 21;14(6):1097-1101. doi: 10.1021/acschembio.9b00069. Epub 2019 May 13. PubMed PMID: 31059217.
  • Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677. doi: 10.1073/pnas.1904099116. Epub 2019 Jun 10. PubMed PMID: 31182571; PubMed Central PMCID: PMC6601261.
  • Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi:10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed PMID: 30799286; PubMed Central PMCID: PMC6506399.
  • Tye BW, Commins N, Ryazanova LV, Wühr M, Springer M, Pincus D, Churchman LS. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Elife. 2019 Mar 7;8. pii: e43002. doi: 10.7554/eLife.43002. PubMed PMID: 30843788; PubMed Central PMCID: PMC6453566.
  • Adam Y, Kim JJ, Lou S, Zhao Y, Xie ME, Brinks D, Wu H, Mostajo-Radji MA, Kheifets S, Parot V, Chettih S, Williams KJ, Gmeiner B, Farhi SL, Madisen L, Buchanan EK, Kinsella I, Zhou D, Paninski L, Harvey CD, Zeng H, Arlotta P, Campbell RE, Cohen AE. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics. Nature. 2019 May;569(7756):413-417. doi: 10.1038/s41586-019-1166-7. Epub 2019 May 1. PubMed PMID: 31043747; PubMed Central PMCID: PMC6613938.
  • Farhi SL, Parot VJ, Grama A, Yamagata M, Abdelfattah AS, Adam Y, Lou S, Kim JJ, Campbell RE, Cox DD, Cohen AE. Wide-Area All-Optical Neurophysiology in Acute Brain Slices. J Neurosci. 2019 Jun 19;39(25):4889-4908. doi:10.1523/JNEUROSCI.0168-19.2019. Epub 2019 Apr 5. PubMed PMID: 30952812.
  • Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL. 6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. Cell Chem Biol. 2019 Jun 4. pii: S2451-9456(19)30175-8. doi: 10.1016/j.chembiol.2019.05.006. [Epub ahead of print] PubMed PMID: 31204288.
  • Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, Sellers WR. The landscape of cancer cell line metabolism. Nat Med. 2019 May;25(5):850-860. doi: 10.1038/s41591-019-0404-8. Epub 2019 May 8. PubMed PMID: 31068703; PubMed Central PMCID: PMC6629041.
  • Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER 3rd, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Aguet F, Weir BA, Rothberg MV, Paolella BR, Lawrence MS, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE, Cherniack AD, Tsherniak A, Vazquez F, Jaffe JD, Lane AA, Weinstock DM, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R, Hahn WC, Getz G, Mills GB, Boehm JS, Golub TR, Garraway LA, Sellers WR. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 May;569(7757):503-508. doi: 10.1038/s41586-019-1186-3. Epub 2019 May 8. PubMed PMID: 31068700.
  • Velilla J, Marchetti MM, Toth-Petroczy A, Grosgogeat C, Bennett AH, Carmichael N, Estrella E, Darras BT, Frank NY, Krier J, Gaudet R, Gupta VA. Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis. Neurol Genet. 2019 Mar 7;5(2):e312. doi:10.1212/NXG.0000000000000312. eCollection 2019 Apr. PubMed PMID: 31041394; PubMed Central PMCID: PMC6454305.
  • Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A. Conservation of the structure and function of  bacterial tryptophan synthases. IUCrJ. 2019 May 29;6(Pt 4):649-664. doi:10.1107/S2052252519005955. eCollection 2019 Jul 1. PubMed PMID: 31316809; PubMed Central PMCID: PMC6608616.
  • Valencia AM, Kadoch C. Chromatin regulatory mechanisms and therapeutic opportunities in cancer. Nat Cell Biol. 2019 Feb;21(2):152-161. doi: 10.1038/s41556-018-0258-1. Epub 2019 Jan 2. Review. PubMed PMID: 30602726.
  • Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D. Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature. 2019 Mar;567(7749):550-553. doi: 10.1038/s41586-019-1039-0. Epub 2019 Mar 20. PubMed PMID: 30894747; PubMed Central PMCID: PMC6629255.
  • Vinyard ME, Su C, Siegenfeld AP, Waterbury AL, Freedy AM, Gosavi PM, Park Y, Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019 May;15(5):529-539. doi: 10.1038/s41589-019-0263-0. Epub 2019 Apr 15. PubMed PMID: 30992567.
  • Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Publisher Correction: Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019 May;15(5):550. doi: 10.1038/s41589-019-0254-1. PubMed PMID: 30858597.
  • Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019 Apr;15(4):419-426. doi: 10.1038/s41589-019-0229-2. Epub 2019 Feb 11. Erratum in:  Nat Chem Biol. 2019 Mar 11;:. PubMed PMID: 30742124; PubMed Central PMCID: PMC6430648.
  • Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Continuous evolution of base editors with expanded target compatibility and improved activity. Nat Biotechnol. 2019 Jul 22. doi: 10.1038/s41587-019-0193-0. [Epub ahead of print] PubMed PMID: 31332326.
  • Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nat Commun. 2019 Apr 26;10(1):1937. doi: 10.1038/s41467-019-09987-0. PubMed PMID: 31028261; PubMed Central PMCID: PMC6486577.
  • Roth TB, Woolston BM, Stephanopoulos G, Liu DR. Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2. ACS Synth Biol. 2019 Apr 19;8(4):796-806. doi: 10.1021/acssynbio.8b00481. Epub 2019 Mar 20. PubMed PMID: 30856338; PubMed Central PMCID: PMC6479731.
  • Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0168-1. PubMed PMID: 31182863.
  • Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019 Jun;37(6):626-631. doi: 10.1038/s41587-019-0134-y. Epub 2019 May 20. Erratum in: Nat Biotechnol. 2019 Jun 10;:. PubMed PMID: 31110355; PubMed Central PMCID: PMC6551276.
  • Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 Mar 26;201(8). pii: e00577-18. doi: 10.1128/JB.00577-18. Print 2019 Apr 15. PubMed PMID: 30692177; PubMed Central
    PMCID: PMC6436352.
  • Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK. Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. Cell Chem Biol. 2019 May 16;26(5):765-777.e3. doi: 10.1016/j.chembiol.2019.02.018. Epub 2019 Apr 4. PubMed PMID: 30956147; PubMed Central PMCID: PMC6526536.
  • Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi:
    10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed PMID: 30799286; PubMed Central PMCID: PMC6506399.
  • Magin RS, Doherty LM, Buhrlage SJ. Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme. Cell Chem Biol. 2019 Feb 21;26(2):153-155. doi: 10.1016/j.chembiol.2019.02.006. PubMed PMID: 30794786.
  • Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S. Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection. J Am Chem Soc. 2019 Aug 2. doi: 10.1021/jacs.9b06061. [Epub ahead of print] PubMed PMID: 31373491.
  • Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. Mol Cell. 2019 Jul 25;75(2):357-371.e7. doi: 10.1016/j.molcel.2019.05.019. Epub 2019 Jun 18. PubMed PMID: 31227231.
  • Fagbami L, Deik AA, Singh K, Santos SA, Herman JD, Bopp SE, Lukens AK, Clish CB, Wirth DF, Mazitschek R. The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling. ACS Infect Dis. 2019 Apr 12;5(4):515-520. doi: 10.1021/acsinfecdis.8b00363. Epub 2019 Feb 21. PubMed PMID: 30773881.
  • Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 May;20(5):664. doi: 10.1038/s41590-019-0361-x. PubMed PMID: 30846880.
  • Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 Mar;20(3):276-287. doi: 10.1038/s41590-018-0303-z. Epub 2019 Jan 28. Erratum in: Nat Immunol. 2019 Mar 7;:. PubMed PMID: 30692621; PubMed Central PMCID: PMC6450391.
  • Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23. PubMed PMID: 30674671; PubMed Central PMCID: PMC6369754.

 

2018

  • Clark AR, Calligaris D, Regan MS, Pomeranz Krummel D, Agar JN, Kallay L, MacDonald T, Schniederjan M, Santagata S, Pomeroy SL, Agar NYR, Sengupta S. Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. J Neurooncol. 2018 Nov;140(2):269-279. doi: 10.1007/s11060-018-2978-2. Epub 2018 Aug 20. PubMed PMID: 30128689; PubMed Central PMCID: PMC6244779.
  • Basu SS, Randall EC, Regan MS, Lopez BGC, Clark AR, Schmitt ND, Agar JN, Dillon DA, Agar NYR. In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture. Anal Chem. 2018 Apr 17;90(8):4987-4991. doi: 10.1021/acs.analchem.8b00530. Epub 2018 Apr 2. PubMed PMID: 29608279; PubMed Central PMCID: PMC6196362.
  • Koppel N, Bisanz JE, Pandelia ME, Turnbaugh PJ, Balskus EP. Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins. Elife. 2018 May 15;7. pii: e33953. doi: 10.7554/eLife.33953. PubMed PMID: 29761785; PubMed Central PMCID: PMC5953540.
  • Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. PubMed PMID: 30102854; PubMed Central PMCID: PMC6333101.
  • Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018 Nov 15;7. pii: e41305. doi: 10.7554/eLife.41305. PubMed PMID: 30431433; PubMed Central PMCID: PMC6277197.
  • Michel BC, D'Avino AR, Cassel SH, Mashtalir N, McKenzie ZM, McBride MJ, Valencia AM, Zhou Q, Bocker M, Soares LMM, Pan J, Remillard DI, Lareau CA, Zullow HJ, Fortoul N, Gray NS, Bradner JE, Chan HM, Kadoch C. A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation. Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5. PubMed PMID: 30397315.
  • Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155. doi: 10.1084/jem.20171066. Epub 2018 Jul 25. PubMed PMID: 30045945; PubMed Central PMCID: PMC6080915.
  • Cohen AE, Farhi SL. Sculpting light to reveal brain function. Nat Neurosci. 2018 Jun;21(6):776-778. doi: 10.1038/s41593-018-0158-5. PubMed PMID: 29802389.
  • Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255. doi:10.1021/acs.jmedchem.7b01655. Epub 2018 Apr 24. PubMed PMID: 29660984; PubMed Central PMCID: PMC6294449.
  • Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. doi:10.1016/j.chembiol.2018.01.013. Epub 2018 Feb 22. PubMed PMID: 29478907; PubMed Central PMCID: PMC5973797.
  • Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545. doi: 10.1021/acsmedchemlett.8b00011. eCollection 2018 Jun 14. PubMed PMID: 29937979; PubMed Central PMCID: PMC6004574.
  • Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory. ACS Chem Neurosci. 2018 Sep 19;9(9):2262-2273. doi: 10.1021/acschemneuro.8b00116. Epub 2018 Jun 22. PubMed PMID: 29932631.
  • Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018 Jul;20(7):745-754. doi: 10.1038/s41556-018-0124-1. Epub 2018 Jun 27. Review. PubMed PMID: 29950572; PubMed Central PMCID: PMC6541229.
  • Wellington S, Hung DT. The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infect Dis. 2018 May 11;4(5):696-714. doi: 10.1021/acsinfecdis.7b00255. Epub 2018 Feb 15. PubMed PMID: 29412643.
  • Levi SM, Li Q, Rötheli AR, Jacobsen EN. Catalytic activation of glycosyl phosphates for stereoselective coupling reactions. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):35-39. doi: 10.1073/pnas.1811186116. Epub 2018 Dec 17. PubMed PMID: 30559190; PubMed Central PMCID: PMC6320501.
  • Mashtalir N, D'Avino AR, Michel BC, Luo J, Pan J, Otto JE, Zullow HJ, McKenzie ZM, Kubiak RL, St Pierre R, Valencia AM, Poynter SJ, Cassel SH, Ranish JA, Kadoch C. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Cell. 2018 Nov 15;175(5):1272-1288.e20. doi:
    10.1016/j.cell.2018.09.032. Epub 2018 Oct 18. PubMed PMID: 30343899.
  • Michel BC, D'Avino AR, Cassel SH, Mashtalir N, McKenzie ZM, McBride MJ, Valencia AM, Zhou Q, Bocker M, Soares LMM, Pan J, Remillard DI, Lareau CA, Zullow HJ, Fortoul N, Gray NS, Bradner JE, Chan HM, Kadoch C. A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation. Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5. PubMed PMID: 30397315.
  • McBride MJ, Pulice JL, Beird HC, Ingram DR, D'Avino AR, Shern JF, Charville GW, Hornick JL, Nakayama RT, Garcia-Rivera EM, Araujo DM, Wang WL, Tsai JW, Yeagley M, Wagner AJ, Futreal PA, Khan J, Lazar AJ, Kadoch C. The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma. Cancer Cell. 2018 Jun 11;33(6):1128-1141.e7. doi: 10.1016/j.ccell.2018.05.002. Epub 2018 May 31. PubMed PMID: 29861296.
  • McBride MJ, Kadoch C. Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities. J Pathol. 2018 Apr;244(5):638-649. doi: 10.1002/path.5042. Epub 2018 Mar 6. Review. PubMed PMID: 29359803.
  • Sherman DJ, Xie R, Taylor RJ, George AH, Okuda S, Foster PJ, Needleman DJ, Kahne D. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Science. 2018 Feb 16;359(6377):798-801. doi: 10.1126/science.aar1886. PubMed PMID: 29449493; PubMed Central PMCID: PMC5858563.
  • Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2359-2364. doi: 10.1073/pnas.1711727115. Epub 2018 Feb 20. PubMed PMID: 29463713; PubMed Central PMCID: PMC5877925.
  • Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D. Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport. J Am Chem Soc. 2018 Jun 6;140(22):6749-6753. doi: 10.1021/jacs.8b02283. Epub 2018 May 16. PubMed PMID: 29746111; PubMed Central PMCID: PMC5990483.
  • Schaefer K, Owens TW, Kahne D, Walker S. Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus. J Am Chem Soc. 2018 Feb 21;140(7):2442-2445. doi: 10.1021/jacs.7b13551. Epub 2018 Feb 9. PubMed PMID: 29402087; PubMed Central PMCID: PMC5870139.
  • Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. PubMed PMID: 29813047; PubMed Central PMCID: PMC6126947.
  • Wang T, Badran AH, Huang TP, Liu DR. Continuous directed evolution of proteins with improved soluble expression. Nat Chem Biol. 2018 Oct;14(10):972-980. doi: 10.1038/s41589-018-0121-5. Epub 2018 Aug 20. PubMed PMID: 30127387; PubMed Central PMCID: PMC6143403.
  • Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2018 Jul;559(7714):E8. doi: 10.1038/s41586-018-0070-x. PubMed PMID: 29720650.
  • Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. 2018 Oct 17;29(10):3245-3249. doi: 10.1021/acs.bioconjchem.8b00563. Epub 2018 Sep 21. PubMed PMID: 30231608; PubMed Central PMCID: PMC6429940.
  • Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. PubMed PMID: 29813047; PubMed Central PMCID: PMC6126947.
  • Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R,  Mitchison TJ. Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14. PubMed PMID: 30429313; PubMed Central PMCID: PMC6275538.
  • Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4. PubMed PMID: 30082792; PubMed Central PMCID: PMC6078993.
  • Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA. Mammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 Sep 4;19(17):1827-1833. doi: 10.1002/cbic.201800214. Epub 2018 Jul 26. PubMed PMID: 29931794; PubMed Central PMCID: PMC6156985.
  • Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018 Sep 25;24(13):3393-3403.e5. doi: 10.1016/j.celrep.2018.08.089. PubMed PMID: 30257201; PubMed Central PMCID: PMC6365304.
  • Wood BM, Santa Maria JP Jr, Matano LM, Vickery CR, Walker S. A partial reconstitution implicates DltD in catalyzing lipoteichoic acid d-alanylation. J Biol Chem. 2018 Nov 16;293(46):17985-17996. doi: 10.1074/jbc.RA118.004561. Epub 2018 Sep 20. PubMed PMID: 30237166; PubMed Central PMCID: PMC6240853.
  • Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix. J Am Chem Soc. 2018 Mar 14;140(10):3510-3513. doi: 10.1021/jacs.7b13546. Epub 2018 Mar 5. PubMed PMID: 29485866; PubMed Central PMCID: PMC5937710.
  • Santiago M, Lee W, Fayad AA, Coe KA, Rajagopal M, Do T, Hennessen F, Srisuknimit V, Müller R, Meredith TC, Walker S. Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic. Nat Chem Biol. 2018 Jun;14(6):601-608. doi: 10.1038/s41589-018-0041-4. Epub 2018 Apr 16. PubMed PMID: 29662210; PubMed Central PMCID: PMC5964011.
  • Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix. J Am Chem Soc. 2018 Mar 14;140(10):3510-3513. doi: 10.1021/jacs.7b13546. Epub 2018 Mar 5. PubMed PMID: 29485866; PubMed Central PMCID: PMC5937710.
  • Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. doi: 10.1021/jacs.8b07328. Epub 2018 Oct 4. PubMed PMID: 30285435; PubMed Central PMCID: PMC6261342.
  • Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10845-10852. doi:10.1073/pnas.1810524115. Epub 2018 Oct 2. PubMed PMID: 30279182; PubMed Central PMCID: PMC6205419.

 

2017

  • Koppel N, Maini Rekdal V, Balskus EP. Chemical transformation of xenobiotics by the human gut microbiota. Science. 2017 Jun 23;356(6344). pii: eaag2770. doi:10.1126/science.aag2770. Review. PubMed PMID: 28642381; PubMed Central PMCID: PMC5534341.
  • Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. doi: 10.1002/anie.201611281. Epub 2017 Apr 18. PubMed PMID: 28418626; PubMed Central PMCID: PMC5967236.
  • Lamberto I, Liu X, Seo HS, Schauer NJ, Iacob RE, Hu W, Das D, Mikhailova T, Weisberg EL, Engen JR, Anderson KC, Chauhan D, Dhe-Paganon S, Buhrlage SJ. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol. 2017 Dec 21;24(12):1490-1500.e11. doi:10.1016/j.chembiol.2017.09.003. Epub 2017 Oct 19. PubMed PMID: 29056421; PubMed Central PMCID: PMC5749250.
  • Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ. Inhibition of USP10 induces degradation of oncogenic FLT3. Nat Chem Biol. 2017 Dec;13(12):1207-1215. doi: 10.1038/nchembio.2486. Epub 2017 Oct 2. PubMed PMID: 28967922; PubMed Central PMCID: PMC6314479.
  • Zalisko BE, Chan C, Denic V, Rock RS, Keenan RJ. Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer. Cell Rep. 2017 Sep 5;20(10):2287-2293. doi: 10.1016/j.celrep.2017.08.035. PubMed PMID: 28877464; PubMed Central PMCID: PMC5657598.
  • Woll KA, Skinner KA, Gianti E, Bhanu NV, Garcia BA, Carnevale V, Eckenhoff RG, Gaudet R. Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling. Biophys J. 2017 Nov 21;113(10):2168-2172. doi: 10.1016/j.bpj.2017.08.040. Epub 2017 Sep 19. PubMed PMID: 28935134; PubMed Central PMCID: PMC5700380.
  • Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14. PubMed PMID: 28805801; PubMed Central PMCID: PMC5693369.
  • She A, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. Cell Chem Biol. 2017 Jul 20;24(7):892-906.e5. doi: 10.1016/j.chembiol.2017.06.010. Epub 2017 Jul 14. PubMed PMID: 28712747; PubMed Central PMCID: PMC5695697.
  • Tyler MW, Zaldivar-Diez J, Haggarty SJ. Correction to "Classics in Chemical Neuroscience: Haloperidol". ACS Chem Neurosci. 2017 Jun 21;8(6):1429. doi:10.1021/acschemneuro.7b00172. Epub 2017 May 16. PubMed PMID: 28510417.
  • Tyler MW, Yourish HB, Ionescu DF, Haggarty SJ. Classics in Chemical Neuroscience: Ketamine. ACS Chem Neurosci. 2017 Jun 21;8(6):1122-1134. doi: 10.1021/acschemneuro.7b00074. Epub 2017 Apr 21. Review. PubMed PMID: 28418641.
  • Tyler MW, Zaldivar-Diez J, Haggarty SJ. Classics in Chemical Neuroscience: Haloperidol. ACS Chem Neurosci. 2017 Mar 15;8(3):444-453. doi:10.1021/acschemneuro.7b00018. Epub 2017 Feb 15. Erratum in: ACS Chem Neurosci.2017 Jun 21;8(6):1429. PubMed PMID: 28170220.
  • Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science. 2017 Nov 17;358(6365):941-946. doi: 10.1126/science.aam9305. Epub 2017 Oct 12. PubMed PMID: 29025995; PubMed Central PMCID: PMC5748897.
  • Spinelli JB, Kelley LP, Haigis MC. An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues. Sci Rep. 2017 Sep 4;7(1):10304. doi: 10.1038/s41598-017-09993-6. PubMed PMID: 28871132; PubMed Central PMCID: PMC5583358.
  • Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3. PubMed PMID: 28671682.
  • Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C. SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat Genet. 2017 Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25. PubMed PMID: 28945250; PubMed Central PMCID: PMC5803080.
  • Otto JE, Kadoch C. A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver. Cancer Cell. 2017 Nov 13;32(5):542-543. doi: 10.1016/j.ccell.2017.10.014. PubMed PMID: 29136498.
  • Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C. SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat Genet. 2017 Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25. PubMed PMID: 28945250; PubMed Central PMCID: PMC5803080.
  • May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport. J Am Chem Soc. 2017 Dec 6;139(48):17221-17224. doi: 10.1021/jacs.7b07736. Epub 2017 Nov 22. PubMed PMID: 29135241; PubMed Central PMCID: PMC5735422.
  • Komor AC, Badran AH, Liu DR. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018 Feb 16;13(2):383-388. doi: 10.1021/acschembio.7b00710. Epub 2017 Oct 9. Review. PubMed PMID: 28957631; PubMed Central PMCID: PMC5891729.
  • Chan AI, McGregor LM, Jain T, Liu DR. Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195. doi: 10.1021/jacs.7b04880. Epub 2017 Jul 20. PubMed PMID: 28689404; PubMed Central PMCID: PMC5575935.
  • Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017 Aug 30;3(8):eaao4774. doi: 10.1126/sciadv.aao4774. eCollection 2017 Aug. PubMed PMID: 28875174; PubMed Central PMCID: PMC5576876.
  • Woolston BM, Roth T, Kohale I, Liu DR, Stephanopoulos G. Development of a formaldehyde biosensor with application to synthetic methylotrophy. Biotechnol Bioeng. 2018 Jan;115(1):206-215. doi: 10.1002/bit.26455. Epub 2017 Nov 3. PubMed PMID: 28921510; PubMed Central PMCID: PMC5699943.
  • Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5. PubMed PMID: 28678785; PubMed Central PMCID: PMC5667900.
  • Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 Dec 2;14(12):1756-1765. doi: 10.1080/15476286.2017.1356566. Epub 2017 Oct 9. PubMed PMID: 28945502; PubMed Central PMCID: PMC5731800.
  • Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Rep. 2017 Mar 14;18(11):2664-2675. doi: 10.1016/j.celrep.2017.02.044. PubMed PMID: 28297670.
  • Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ. Inhibition of USP10 induces degradation of oncogenic FLT3. Nat Chem Biol. 2017 Dec;13(12):1207-1215. doi: 10.1038/nchembio.2486. Epub 2017 Oct 2. PubMed PMID: 28967922; PubMed Central PMCID: PMC6314479.
  • Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure. 2018 Jan 2;26(1):153-160.e4. doi: 10.1016/j.str.2017.11.016. Epub 2017 Dec 21. PubMed PMID: 29276033; PubMed Central PMCID: PMC5947960.
  • Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139(31):10597-10600. doi: 10.1021/jacs.7b04726. Epub 2017 Jul 28. PubMed PMID: 28727445; PubMed Central PMCID: PMC5699463.
  • Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139(31):10597-10600. doi: 10.1021/jacs.7b04726. Epub 2017 Jul 28. PubMed PMID: 28727445; PubMed Central
    PMCID: PMC5699463.
  • Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nat Chem Biol. 2017 Apr;13(4):396-401. doi: 10.1038/nchembio.2302. Epub 2017 Feb 6. PubMed PMID: 28166208; PubMed Central PMCID: PMC5362317.
  • Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. J Am Chem Soc. 2017 Jul 26;139(29):9791-9794. doi: 10.1021/jacs.7b04881. Epub 2017 Jul 11. PubMed PMID:
    28691491; PubMed Central PMCID: PMC5613940.
  • Wang H, Feng Z, Lu A, Jiang Y, Wu H, Xu B. Instant Hydrogelation Inspired by Inflammasomes. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7579-7583. doi:10.1002/anie.201702783. Epub 2017 May 24. PubMed PMID: 28481474; PubMed Central PMCID: PMC5551645.

 

2016

  • Koppel N, Balskus EP. Exploring and Understanding the Biochemical Diversity of the Human Microbiota. Cell Chem Biol. 2016 Jan 21;23(1):18-30. doi: 10.1016/j.chembiol.2015.12.008. Review. PubMed PMID: 26933733.
  • Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer E, Letai A, Barry WT, Carroll JS, Long H, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016 Jan 21;529(7586):413-417. doi: 10.1038/nature16508. Epub 2016 Jan 6. PubMed PMID: 26735014; PubMed Central PMCID: PMC4854653.
  • Koblan LW, Buckley DL, Ott CJ, Fitzgerald ME, Ember SW, Zhu JY, Liu S, Roberts JM, Remillard D, Vittori S, Zhang W, Schonbrunn E, Bradner JE. Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET. ChemMedChem. 2016 Dec 6;11(23):2575-2581. doi: 10.1002/cmdc.201600502. Epub 2016 Nov 15. PubMed PMID: 27862999.
  • Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N. Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7894-9. doi:10.1073/pnas.1605015113. Epub 2016 Jun 27. PubMed PMID: 27354530; PubMed Central PMCID: PMC4948368.
  • Cantley AM, Woznica A, Beemelmanns C, King N, Clardy J. Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J Am Chem Soc. 2016 Apr 6;138(13):4326-9. doi: 10.1021/jacs.6b01190. Epub 2016 Mar 24. PubMed PMID: 26998963; PubMed Central PMCID: PMC4968929.
  • Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, Gray NS, Xavier RJ. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 Aug 19;11(8):2105-11. doi: 10.1021/acschembio.6b00217. Epub 2016 Jun 6. PubMed PMID: 27224444; PubMed Central PMCID: PMC4992440.
  • Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Sci Transl Med. 2016 Aug 10;8(351):351ra106. doi: 10.1126/scitranslmed.aaf7551. PubMed PMID: 27510902; PubMed Central PMCID: PMC5784409.
  • Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chem Biol. 2016 Jun 23;23(6):666-77. doi: 10.1016/j.chembiol.2016.05.011. Epub 2016 Jun 16. PubMed PMID: 27321573; PubMed Central PMCID: PMC4920728.
  • Simpson BW, Owens TW, Orabella MJ, Davis RM, May JM, Trauger SA, Kahne D, Ruiz N. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. MBio. 2016 Oct 18;7(5). pii: e01729-16. doi: 10.1128/mBio.01729-16. PubMed PMID: 27795402; PubMed Central PMCID: PMC5082905.
  • Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R. Compounds that select against the tetracycline-resistance efflux pump. Nat Chem Biol. 2016 Nov;12(11):902-904. doi: 10.1038/nchembio.2176. Epub 2016 Sep 19. PubMed PMID: 27642863; PubMed Central PMCID: PMC5069154.
  • Baym M, Stone LK, Kishony R. Multidrug evolutionary strategies to reverse antibiotic resistance. Science. 2016 Jan 1;351(6268):aad3292. doi: 10.1126/science.aad3292. Review. PubMed PMID: 26722002; PubMed Central PMCID: PMC5496981.
  • Badran AH, Guzov VM, Huai Q, Kemp MM, Vishwanath P, Kain W, Nance AM, Evdokimov A, Moshiri F, Turner KH, Wang P, Malvar T, Liu DR. Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance. Nature. 2016 May 5;533(7601):58-63. doi: 10.1038/nature17938. Epub 2016 Apr 27. PubMed PMID: 27120167; PubMed Central PMCID: PMC4865400.
  • Aleem S, Georghiou G, Kleiner RE, Guja K, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chem Biol. 2016 Sep 22;23(9):1103-1112. doi: 10.1016/j.chembiol.2016.07.017. Epub 2016 Sep 1. PubMed PMID: 27593110; PubMed Central PMCID: PMC5096457.
  • Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7. PubMed PMID: 27602946; PubMed Central PMCID: PMC5515376.
  • Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7. PubMed PMID: 26953159; PubMed Central PMCID: PMC4878416.
  • Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7. PubMed PMID: 26640968.
  • Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882. PubMed PMID: 26947396; PubMed Central PMCID: PMC4786681.
  • Matano LM, Morris HG, Wood BM, Meredith TC, Walker S. Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening. Bioorg Med Chem. 2016 Dec 15;24(24):6307-6314. doi: 10.1016/j.bmc.2016.08.003. Epub 2016 Aug 16. PubMed PMID: 27594549; PubMed Central PMCID: PMC5180449.
  • Levine ZG, Walker S. The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells? Annu Rev Biochem. 2016 Jun 2;85:631-57. doi: 10.1146/annurev-biochem-060713-035344. Review. PubMed PMID: 27294441.
  • Rajagopal M, Martin MJ, Santiago M, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S. Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. MBio. 2016 Aug 16;7(4). pii: e00950-16. doi: 10.1128/mBio.00950-16. PubMed PMID: 27531908; PubMed Central PMCID: PMC4992970.
  • Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13. PubMed PMID: 27746017; PubMed Central PMCID: PMC5089849.
  • Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11. PubMed PMID: 27069117; PubMed Central PMCID: PMC4854733.
  • Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4. PubMed PMID: 27043298; PubMed Central PMCID: PMC4856535.

 

2015

  • Cantley AM, Clardy J. Animals in a bacterial world: opportunities for chemical ecology. Nat Prod Rep. 2015 Jul;32(7):888-92. doi: 10.1039/c4np00141a. Review. PubMed PMID: 25656944; PubMed Central PMCID: PMC4724392.
  • Chien MP, Werley CA, Farhi SL, Cohen AE. Photostick: a method for selective isolation of target cells from culture. Chem Sci. 2015 Mar;6(3):1701-1705. PubMed PMID: 25705368; PubMed Central PMCID: PMC4334133.
  • Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-606. doi:10.1021/acs.jmedchem.5b00710. Epub 2015 Aug 18. PubMed PMID: 26258521; PubMed Central PMCID: PMC4777322.
  • Wivagg CN, Wellington S, Gomez JE, Hung DT. Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis. ACS Infect Dis. 2016 Feb 12;2(2):104-10. doi:
    10.1021/acsinfecdis.5b00119. Epub 2015 Dec 21. PubMed PMID: 27624961.
  • Badran AH, Liu DR. Development of potent in vivo mutagenesis plasmids with broad mutational spectra. Nat Commun. 2015 Oct 7;6:8425. doi: 10.1038/ncomms9425. PubMed PMID: 26443021; PubMed Central PMCID: PMC4633624.
  • Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nat Methods. 2015 Oct;12(10):939-42. doi: 10.1038/nmeth.3515. Epub 2015 Aug 10. PubMed PMID: 26258293; PubMed Central PMCID: PMC4589463.
  • Chan AI, McGregor LM, Liu DR. Novel selection methods for DNA-encoded chemical libraries. Curr Opin Chem Biol. 2015 Jun;26:55-61. doi: 10.1016/j.cbpa.2015.02.010. Epub 2015 Feb 24. Review. PubMed PMID: 25723146; PubMed Central PMCID: PMC4475454.
  • Brancucci NM, Goldowitz I, Buchholz K, Werling K, Marti M. An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development. Nat Protoc. 2015 Aug;10(8):1131-42. doi: 10.1038/nprot.2015.072. Epub 2015 Jul 2. PubMed PMID: 26134953; PubMed Central PMCID: PMC4581880.
  • Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ; LSFC Consortium, Vachon L, Morin C, Laprise C, Rioux JD, Mootha VK, Des Rosiers C. A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome. Cell Rep. 2015 Nov 3;13(5):981-9. doi: 10.1016/j.celrep.2015.09.054. Epub 2015 Oct 22. PubMed PMID: 26565911; PubMed Central PMCID: PMC4644511.
  • Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16;137(49):15378-81. doi: 10.1021/jacs.5b10596. Epub 2015 Dec 3. PubMed PMID: 26583201; PubMed Central PMCID: PMC4697197.
  • Pasquina L, Santa Maria JP Jr, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol. 2016 Jan;12(1):40-5. doi: 10.1038/nchembio.1967. Epub 2015 Nov 30. PubMed PMID: 26619249; PubMed Central PMCID: PMC4684722.
  • Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC. A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics. 2015 Mar 29;16:252. doi: 10.1186/s12864-015-1361-3. PubMed PMID: 25888466; PubMed Central PMCID: PMC4389836.
  • Pasquina L, Santa Maria JP Jr, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol. 2016 Jan;12(1):40-5. doi: 10.1038/nchembio.1967. Epub 2015 Nov 30. PubMed PMID: 26619249; PubMed Central PMCID: PMC4684722.
  • Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC. A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics. 2015 Mar 29;16:252. doi: 10.1186/s12864-015-1361-3. PubMed PMID: 25888466; PubMed Central PMCID: PMC4389836.
  • Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. PubMed PMID: 25751766; PubMed Central PMCID: PMC4475500.
  • Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. PubMed PMID: 25751766; PubMed Central PMCID: PMC4475500.
  • Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discov. 2015;1. pii: 15013. Epub 2015 Jun 23. PubMed PMID: 26583071; PubMed Central PMCID: PMC4646227.
  • Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments. J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14. PubMed PMID:  26468282; PubMed Central PMCID: PMC4705927.
  • Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8. PubMed PMID: 26449474; PubMed Central PMCID: PMC4640189.

 

2014

  • Sörensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G, Eggert US. The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol. 2012 Sep 21;7(9):1502-8. PMCID: PMC3448819.
  • Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7. doi:10.1073/pnas.1302257110. Epub 2013 May 28. PubMed PMID: 23716698; PubMed Central PMCID: PMC3683768.
  • Lee S, Braun CR, Bird GH, Walensky LD. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014;544:25-48. doi: 10.1016/B978-0-12-417158-9.00002-9. PubMed PMID: 24974285.
  • Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic BAK. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E986-95. doi: 10.1073/pnas.1214313110. Epub 2013 Feb 12. PubMed PMID: 23404709; PubMed Central PMCID: PMC3600461.
  • Carlson, J. C.; Badran, A. H.; Guggiana-Nilo, D. A.; Liu, D. R. (2014) Negative selection and stringency modulation in phage-assisted continuous evolution. Nature Chemical Biology, 10, 216-222 PMCID: PMC3977541
  • Freinkman E, Okuda S, Ruiz N, Kahne D. Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry. 2012 Jun 19;51(24):4800-6. doi: 10.1021/bi300592c. Epub 2012 Jun 8. PubMed PMID: 22668317; PubMed Central PMCID: PMC3426634.
  • Okuda S, Freinkman E, Kahne D. Cytoplasmic ATP hydrolysis powers transport of  lipopolysaccharide across the periplasm in E. coli. Science. 2012 Nov 30;338(6111):1214-7. doi: 10.1126/science.1228984. Epub 2012 Nov 8. PubMed PMID: 23138981; PubMed Central PMCID: PMC3552488.
  • Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28;494(7438):480-3. doi: 10.1038/nature11897. PubMed PMID: 23446419; PubMed Central PMCID: PMC3730528.
  • McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc. 2014 Feb 26;136(8):3264-70. doi: 10.1021/ja412934t. Epub 2014 Feb 17. PubMed PMID: 24495225; PubMed Central PMCID: PMC3985698.
  • Santa Maria JP Jr, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12510-5. doi: 10.1073/pnas.1404099111. Epub 2014 Aug 7. PubMed PMID:25104751; PubMed Central PMCID: PMC4151746.
  • McKeown MR, Bradner JE. Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med. 2014 Oct 1;4(10). pii: a014266. doi: 10.1101/cshperspect.a014266. PubMed PMID: 25274755.
  • McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. PubMed PMID: 25314271; PubMed Central PMCID: PMC4234447.
  • Strittmatter, L., Li, Y., Nakatsuka, N.J., Calvo, S.E., Grabarek, Z., Mootha, V.K., 2014, “CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity,” Hum. Mol. Genet., 23(9):2313-23. PMCID 24334609
  • Tan JL, Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011;105:493-516. doi: 10.1016/B978-0-12-381320-6.00021-7. PubMed PMID: 21951544.
  • Nguyen PA,  Groen AC,  Loose M,  Ishihara K,  Wühr M,  Field CM,  Mitchison TJ., Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science. 2014 Oct 10;346(6206):244-7. doi: 10.1126/science.1256773. PubMed PMID: 25301629.
  • Ankarklev J, Brancucci NM, Goldowitz I, Mantel PY, Marti M. Sex: how malaria parasites get turned on. Curr Biol. 2014 May 5;24(9):R368-70. doi:
    10.1016/j.cub.2014.03.046. PubMed PMID: 24801188.
  • Badran AH, Liu DR. In vivo continuous directed evolution. Curr Opin Chem Biol. 2014 Nov 7;24C:1-10. doi: 10.1016/j.cbpa.2014.09.040. [Epub ahead of print] Review. PubMed PMID: 25461718.
  • Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schroder, G. F., Fitzgerald, K. A., Wu, H. & Egelman, E. H. (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Cell. 156, 1193-206. PMID: 24630722
  • Lu, A., Kabaleeswaran, V., Fu, T., Magupalli, V. G. & Wu, H. (2014) Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions, Journal of molecular biology. 426, 1420-7. PMID: 24406744
  • Federation, A.J., Bradner, J.E., Meissner, A., 2014, “The use of small molecules in somatic-cell reprogramming.” Trends in cell biology, 24:179-87. PMID: 24183602
  • Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc. 2014 Oct 22;136(42):14678-81. doi:10.1021/ja508147s. Epub 2014 Oct 10. PubMed PMID: 25291014; PubMed Central PMCID:PMC4210121.
  • Wang F, Chan C, Weir NR, Denic V. The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature. 2014 Aug
    28;512(7515):441-4. doi: 10.1038/nature13471. Epub 2014 Jul 20. PubMed PMID:25043001.
  • Sourav Banerjee, S., Buhrlage, S.J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A.R., Alessi, D.R., Gray, N.S., 2014, "Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases," Biochem. J. 457, 215-225. PMCID: PMC3969223
  • Meier, B.C. and Wagner, B.K., 2014, "Inhibition of HDAC3 as a Strategy for Developing Novel Diabetes Therapeutics," Epigenomics, 6(2): 209-214, PMID: 24811789.
  • Hochbaum, D.R., Zhao, Y., Farhi, S.L., Klapoetke, N., Werley, C.A., Kapoor, V., Kralj, J.M., Maclaurin, D., Smedemark-Margulies, N., Saulnier, J.L., Boulting, G.L., Straub, C., Cho, Y.K., Melkonian, M., Wong, G.K., Harrison, D.J., Murthy, V.N., Sabatini, B.L., Boyden, E.S., Campbell, R.E., and Cohen, A.E., 2014, "All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins," Nature Methods, Vol 11, 825-33. PMCID: PMC4117813

 

2013

  • Lajoie MJ, Kosuri S, Mosberg JA, Gregg CJ, Zhang D, Church GM. Probing the limits of genetic recoding in essential genes. Science. 2013 Oct 18;342(6156):361-3. doi: 10.1126/science.1241460. PubMed PMID: 24136967.

  • Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically recoded organisms expand biological functions. Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459. PubMed PMID: 24136966.

  • Ling J, Daoud R, Lajoie MJ, Church GM, Söll D, Lang BF. Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucleic Acids Res. 2014 Jan;42(1):499-508. doi: 10.1093/nar/gkt842. Epub 2013 Sep 17. PubMed PMID:24049072; PubMed Central PMCID: PMC3874161.

  • Pasquina LW, Santa Maria JP, Walker S. Teichoic acid biosynthesis as an antibiotic target. Curr Opin Microbiol. 2013 Oct;16(5):531-7. doi:10.1016/j.mib.2013.06.014. Epub 2013 Jul 31. Review. PubMed PMID: 23916223; PubMed Central PMCID: PMC3834221.

  • Brown S, Santa Maria JP Jr, Walker S. Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol. 2013;67:313-36. doi:10.1146/annurev-micro-092412-155620. Review. PubMed PMID: 24024634; PubMed Central PMCID: PMC3883102

  • Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

  • Mantel, P. Y., *A. N. Hoang, *I. Goldowitz, *D. Potashnikova, B. Hamza, I. A. Vorobjev, I. Ghiran, M. Toner, D. Irimia, R. Ivanov, N. Barteneva, M. Marti (2013). Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host and Microbe 13, 521-534. PMID: 23684304

  • Kawate, T., Iwase, N., Shimizu, M., Stanley, S.A., Wellington, S., Kazyanskaya, E., Hung, D.T. (2013). Synthesis and Structure-Activity Relationships of Phenyl-substituted Coumarins with anti-tubercular
    activity that target FadD32, Bioorganic & Medicinal Chemistry Letters 23(22), 6052–6059. doi:10.1016/j.bmcl.2013.09.035. Epub 2013 Sept 19. Pubmed PMID:24103299

 

2012

  • Yuan Yuan, Qiu Wang, Joshiawa Paulk, Stefan Kubicek, Melissa M. Kemp, Drew J. Adams, Alykhan F. Shamji, Bridget K. Wagner, and Stuart L. Schreiber. 1. A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma. ACS Chemical Biology 2012 7 (7), 1152-1157. PMCID:PMC3401036
  • Carr PA*, Wang HH*, Sterling B*, Isaacs FJ, Lajoie MJ, Xu G, Church GM, Jacobson JM (2012) Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. NAR; doi: 10.1093/nar/gks455
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mitchison T, Wühr M, Nguyen PA, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken). 2012 Oct;69(10):738-50. doi:
  • Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Hong Lim JC, Pei-Ying Sim C, Chu YS; WCR participants, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. The first World Cell Race. Curr Biol. 2012 Sep 11;22(17):R673-5. 
  • Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17; 150(4):673-684
  • Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Curr Biol. 2012 May 22;22(10):R409-11. 
  • Leoni V*, Strittmatter L*, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab. 2012 Mar;105(3):463-71 (* indicates equal contribution)
  • Weigert O, Lane AA, Bird L, Kopp N, Chapuy B, van Bodegom D, Toms AV, Marubayashi S, Christie AL, McKeown M, Paranal RM, Bradner JE, Yoda A, Gaul C, Vangrevelinghe E, Romanet V, Murakami M, Tiedt R, Ebel N, Evrot E, De Pover A, Régnier CH, Erdmann D, Hofmann F, Eck MJ, Sallan SE, Levine RL, Kung AL, Baffert F, Radimerski T, Weinstock DM. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012 Feb 13; 208(2):259-73
  • Nakamura H, Hamer HA, Sirasani G, Balskus EP. Cylindrocyclophane Biosynthesis Involves Functionalization of an Unactivated Carbon Center.JACS 2012 ASAP.
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751

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