2020

2019

2018

2017

2016

2015

2014

2013

2012

2020

  • Kim HK, Lee S, Kim Y, Park J, Min S, Choi JW, Huang TP, Yoon S, Liu DR, Kim HH. High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells. Nat Biomed Eng. 2020 Jan;4(1):111-124. doi: 10.1038/s41551-019-0505-1. Epub 2020 Jan 14. PMID: 31937939.
  • Levy JM, Yeh WH, Pendse N, Davis JR, Hennessey E, Butcher R, Koblan LW, Comander J, Liu Q, Liu DR. Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses. Nat Biomed Eng. 2020 Jan;4(1):97-110. doi: 10.1038/s41551-019-0501-5. Epub 2020 Jan 14. PMID: 31937940; PMCID: PMC6980783.
  • Li Z*, Pinch BJ*, Olson CM, Donovan KA, Nowak RP, Mills CE, Scott DA, Doctor ZM, Eleuteri NA, Chung M, Sorger PK, Fischer ES, Gray NS. Development and Characterization of a Wee1 Kinase Degrader. Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9. doi: 10.1016/j.chembiol.2019.10.013. Epub 2019 Nov 14. PMID: 31735695; PMCID: PMC6980656.
  • Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W. Adenine base editing in an adult mouse model of tyrosinaemia. Nat Biomed Eng. 2020 Jan;4(1):125-130. doi: 10.1038/s41551-019-0357-8. Epub 2019 Feb 25. PMID: 31740768; PMCID: PMC6986236.
  • You I, Erickson EC, Donovan KA, Eleuteri NA, Fischer ES, Gray NS, Toker A. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. doi: 10.1016/j.chembiol.2019.11.014. Epub 2019 Dec 16. PMID: 31859249; PMCID: PMC6980747.
  • Groendyke BJ, Powell CE, Feru F, Gero TW, Li Z, Szabo H, Pang K, Feutrill J, Chen B, Li B, Gray NS, Scott DA. Benzopyrimidodiazepinone inhibitors of TNK2. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126948. doi: 10.1016/j.bmcl.2020.126948. Epub 2020 Jan 7. PMID: 31928839.
  • Melms JC, Vallabhaneni S, Mills CE, Yapp C, Chen JY, Morelli E, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ, Miller DM, Spektor A, Schadendorf D, Riggi N, Wucherpfennig KW, Sorger PK, Izar B. Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer Res. 2020 Feb 15;80(4):798-810. doi: 10.1158/0008-5472.CAN-19-2330. Epub 2019 Dec 27. PMID: 31882401; PMCID: PMC7029677.
  • Xu G, Chhangawala S, Cocco E, Razavi P, Cai Y, Otto JE, Ferrando L, Selenica P, Ladewig E, Chan C, Da Cruz Paula A, Witkin M, Cheng Y, Park J, Serna-Tamayo C, Zhao H, Wu F, Sallaku M, Qu X, Zhao A, Collings CK, D'Avino AR, Jhaveri K, Koche R, Levine RL, Reis-Filho JS, Kadoch C, Scaltriti M, Leslie CS, Baselga J, Toska E. ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat Genet. 2020 Feb;52(2):198-207. doi: 10.1038/s41588-019-0554-0. Epub 2020 Jan 13. PMID: 31932695; PMCID: PMC7341683.
  • Schauer NJ, Magin RS, Liu X, Doherty LM, Buhrlage SJ. Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem. 2020 Mar 26;63(6):2731-2750. Review. doi: 10.1021/acs.jmedchem.9b01138. Epub 2019 Nov 20. PMID: 31682427.
  • Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326. doi: 10.1038/s41589-020-0467-3. Epub 2020 Feb 10. PMID: 32042200; PMCID: PMC7036035.
  • Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Rep. 2020 Mar 10;30(10):3229-3239.e6. doi: 10.1016/j.celrep.2020.02.057. PMID: 32160532; PMCID: PMC7343539.
  • Do T, Page JE, Walker S. Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes. J Biol Chem. 2020 Mar 6;295(10):3347-3361. Review. doi: 10.1074/jbc.REV119.010155. Epub 2020 Jan 23. PMID: 31974163; PMCID: PMC7062177.
  • Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, Ray A, Chauhan D, Dhe-Paganon S, Anderson KC, Griffin JD, Li J, Hahn WC, Sorger PK, Engen JR, Stegmaier K, Marto JA, Buhrlage SJ. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep. 2020 Mar 24;10(1):5324. doi: 10.1038/s41598-020-62076-x. PMID: 32210275; PMCID: PMC7093416.
  • Bollenbach M, Ortega M, Orman M, Drennan CL, Balskus EP. Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. ACS Med Chem Lett. 2020 Mar 25;11(10):1980-1985. doi: 10.1021/acsmedchemlett.0c00005. PMID: 33062182; PMCID: PMC7549264.
  • Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. J Am Chem Soc. 2020 Apr 8;142(14):6477-6482. doi: 10.1021/jacs.0c00099. Epub 2020 Mar 16. PMID: 32175731; PMCID: PMC7146867.
  • Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR. Continuous evolution of SpCas9 variants compatible with non-G PAMs. Nat Biotechnol. 2020 Apr;38(4):471-481. doi: 10.1038/s41587-020-0412-8. Epub 2020 Feb 10. PMID: 32042170; PMCID: PMC7145744.
  • Susa KJ, Seegar TC, Blacklow SC, Kruse AC. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 Apr 27;9:e52337. doi: 10.7554/eLife.52337. PMID: 32338599; PMCID: PMC7228769.
  • Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA. Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis. Cell Rep. 2020 May 12;31(6):107623. doi: 10.1016/j.celrep.2020.107623. PMID: 32402282; PMCID: PMC7433758.
  • Doman JL*, Raguram A*, Newby GA, Liu DR. Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nat Biotechnol. 2020 May;38(5):620-628. doi: 10.1038/s41587-020-0414-6. Epub 2020 Feb 10. PMID: 32042165; PMCID: PMC7335424.
  • Lin Q, Zong Y, Xue C, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C. Prime genome editing in rice and wheat. Nat Biotechnol. 2020 May;38(5):582-585. doi: 10.1038/s41587-020-0455-x. Epub 2020 Mar 16. PMID: 32393904.
  • Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6. doi: 10.1016/j.chembiol.2020.04.004. Epub 2020 May 14. PMID: 32413285; PMCID: PMC7405809.
  • Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S. The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity. J Bacteriol. 2020 Jun 1:JB.00149-20. doi: 10.1128/JB.00149-20. Epub ahead of print. PMID: 32482719.
  • Tan ZW*, Fei G,* Paulo JA, Bellaousov S, Martin SES, Duveau DY, Thomas CJ, Gygi SP, Boutz PL, Walker S. O-GlcNAc regulates gene expression by controlling detained intron splicing. Nucleic Acids Res. 2020 Jun 4;48(10):5656-5669. doi: 10.1093/nar/gkaa263. PMID: 32329777; PMCID: PMC7261177.
  • Wilson C*, Chen PJ*, Miao Z, Liu DR. Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase. Nat Biotechnol. 2020 Jun 29. doi: 10.1038/s41587-020-0572-6. Epub ahead of print. PMID: 32601430.
  • Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness. Sci Transl Med. 2020 Jun 3;12(546):eaay9101. doi: 10.1126/scitranslmed.aay9101. PMID: 32493795.
  • Anzalone AV*, Koblan LW*, Liu DR. Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors. Nat Biotechnol. 2020 Jul;38(7):824-844. doi: 10.1038/s41587-020-0561-9. Epub 2020 Jun 22. PMID: 32572269.
  • Baranov E*, McBride MJ*, Bellizzi AM, Ligon AH, Fletcher CDM, Kadoch C, Hornick JL. A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma. Am J Surg Pathol. 2020 Jul;44(7):922-933. doi: 10.1097/PAS.0000000000001447. PMID: 32141887; PMCID: PMC7289668
  • Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure. 2020 Jul 7;28(7):847-857.e5. doi: 10.1016/j.str.2020.04.011. Epub 2020 Apr 30. PMID: 32359398; PMCID: PMC7427690.
  • Hauseman ZJ*, Harvey EP*, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Mol Cell. 2020 Jul 2;79(1):68-83.e7. doi: 10.1016/j.molcel.2020.05.029. Epub 2020 Jun 12. PMID: 32533918; PMCID: PMC7472837.
  • Li Q, Levi SM, Jacobsen EN. Highly Selective β-Mannosylations and β-Rhamnosylations Catalyzed by Bis-thiourea. J Am Chem Soc. 2020 Jul 8;142(27):11865-11872. doi: 10.1021/jacs.0c04255. Epub 2020 Jun 26. PMID: 32527078; PMCID: PMC7523191.
  • Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. 2020 Jul;583(7817):631-637. doi: 10.1038/s41586-020-2477-4. Epub 2020 Jul 8. PMID: 32641830; PMCID: PMC7381381.
  • Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nat Biotechnol. 2020 Jul;38(7):883-891. doi: 10.1038/s41587-020-0453-z. Epub 2020 Mar 16.: PMID: 32433547; PMCID: PMC7357821.
  • Kenny DJ, Plichta DR, Shungin D, Koppel N, Hall AB, Fu B, Vasan RS, Shaw SY, Vlamakis H, Balskus EP, Xavier RJ. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level. Cell Host Microbe. 2020 Aug 12;28(2):245-257.e6. doi: 10.1016/j.chom.2020.05.013. Epub 2020 Jun 15. PMID: 32544460; PMCID: PMC7435688.
  • Manohar S, Yu Q, Gygi SP, King RW. The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint. Mol Cell Proteomics.2020 Sep;19(9):1450-1467. doi: 10.1074/mcp.RA120.002069. Epub 2020 Jun 18. PMID: 32554797.
  • Bushman JW, Donovan KA, Schauer NJ, Liu X, Hu W, Varca AC, Buhrlage SJ, Fischer ES. Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors. Cell Chem Biol. 2020 Sep 23:S2451-9456(20)30377-9. doi: 10.1016/j.chembiol.2020.09.005. Epub ahead of print. PMID: 33007217.
  • McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, Seo HS, Umbreit NT, St Pierre R, Valencia AM, Qian K, Zullow HJ, Jaffe JD, Dhe-Paganon S, Muir TW, Kadoch C. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020Sep;27(9):836-845. doi: 10.1038/s41594-020-0466-9. Epub 2020 Aug 3. PMID: 32747783.
  • Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. PMID: 32483379; PMCID: PMC7442691.
  • Berginski ME, Moret N, Liu C, Goldfarb D, Sorger PK, Gomez SM. The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases. Nucleic Acids Res. 2020Oct 20:gkaa853. doi: 10.1093/nar/gkaa853. Epub ahead of print. PMID: 33079988.
  • Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S. Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9. Mol Cancer Res. 2020 Oct;18(10):1512-1521. doi: 10.1158/1541-7786.MCR-20-0339. Epub 2020 Jul 1. PMID: 32611550; PMCID: PMC7541471.
  • Li Z, Powell CE, Groendyke BJ, Gero TW, Feru F, Feutrill J, Chen B, Li B, Szabo H, Gray NS, Scott DA. Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127456. doi: 10.1016/j.bmcl.2020.127456. Epub 2020 Jul 31. PMID: 32739400.
  • Mashtalir N, Suzuki H, Farrell DP, Sankar A, Luo J, Filipovski M, D'Avino AR, St Pierre R, Valencia AM, Onikubo T, Roeder RG, Han Y, He Y, Ranish JA, DiMaio F, Walz T, Kadoch C. A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms. Cell. 2020 Oct 29;183(3):802-817.e24. doi: 10.1016/j.cell.2020.09.051. Epub 2020 Oct 13. PMID: 33053319; PMCID: PMC7717177.
  • Powell CE, Du G, Che J, He Z, Donovan KA, Yue H, Wang ES, Nowak RP, Zhang T, Fischer ES, Gray NS. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730. doi: 10.1021/acschembio.0c00520. Epub 2020 Sep 28. PMID: 32865967.
  • Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020 Nov;16(11):1218-1226. doi: 10.1038/s41589-020-0625-7. Epub 2020 Aug 17. PMID: 32807965.
  • Hesser AR, Schaefer K, Lee W, Walker S. Lipoteichoic acid polymer length is determined by competition between free starter units. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29669-29676. doi: 10.1073/pnas.2008929117. Epub 2020 Nov 10. PMID: 33172991; PMCID: PMC7703640.
  • Shrock E*, Fujimura E*, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A, Li JZ, Khatri A, Chu HY; MGH COVID-19 Collection & Processing Team, Villani AC, Kays K, Goldberg MB, Hacohen N, Filbin MR, Yu XG, Walker BD, Wesemann DR, Larman HB, Lederer JA, Elledge SJ. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 Nov 27;370(6520):eabd4250. doi: 10.1126/science.abd4250. Epub 2020 Sep 29. PMID: 32994364.
  • Pelletier JF, Field CM, Fürthauer S, Sonnett M, Mitchison TJ. Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 2020 Dec 7;9:e60047. doi: 10.7554/eLife.60047. PMID: 33284105; PMCID: PMC7759381.
  • Barish S, Barakat TS, Michel BC, Mashtalir N, Phillips JB, Valencia AM, Ugur B, Wegner J, Scott TM, Bostwick B; Undiagnosed Diseases Network, Murdock DR, Dai H, Perenthaler E, Nikoncuk A, van Slegtenhorst M, Brooks AS, Keren B, Nava C, Mignot C, Douglas J, Rodan L, Nowak C, Ellard S, Stals K, Lynch SA, Faoucher M, Lesca G, Edery P, Engleman KL, Zhou D, Thiffault I, Herriges J, Gass J, Louie RJ, Stolerman E, Washington C, Vetrini F, Otsubo A, Pratt VM, Conboy E, Treat K, Shannon N, Camacho J, Wakeling E, Yuan B, Chen CA, Rosenfeld JA, Westerfield M, Wangler M, Yamamoto S, Kadoch C, Scott DA, Bellen HJ. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Am J Hum Genet. 2020 Dec 3;107(6):1096-1112. doi: 10.1016/j.ajhg.2020.11.003. Epub 2020 Nov 23. PMID: 33232675.
  • Donovan KA, Ferguson FM, Bushman JW, Eleuteri NA, Bhunia D, Ryu S, Tan L, Shi K, Yue H, Liu X, Dobrovolsky D, Jiang B, Wang J, Hao M, You I, Teng M, Liang Y, Hatcher J, Li Z, Manz TD, Groendyke B, Hu W, Nam Y, Sengupta S, Cho H, Shin I, Agius MP, Ghobrial IM, Ma MW, Che J, Buhrlage SJ, Sim T, Gray NS, Fischer ES. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10. doi: 10.1016/j.cell.2020.10.038. Epub 2020 Dec 3. PMID: 33275901.
  • Morgenlander WR, Henson S, Monaco D, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Balagopal A, Sullivan D, Shoham S, Quinn TC, Eshleman S, Casadevall A, Redd AD, Laeyendecker O, Ackerman ME, Pekosz A, Elledge SJ, Robinson M, Tobian AAR, Larman HB. Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. medRxiv [Preprint]. 2020 Dec 
  • van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 Sep 1;32(3):391-403.e6. doi: 10.1016/j.cmet.2020.07.009. Epub 2020 Aug 6. PMID: 32763164.

2019

  • Basu SS, Regan MS, Randall EC, Abdelmoula WM, Clark AR, Gimenez-Cassina Lopez B, Cornett DS, Haase A, Santagata S, Agar NYR. Rapid MALDI mass spectrometry imaging for surgical pathology. NPJ Precis Oncol. 2019 Jul 4;3:17. doi: 10.1038/s41698-019-0089-y. eCollection 2019. PubMed PMID: 31286061; PubMed Central PMCID: PMC6609678.
  • Basu SS, McMinn MH, Giménez-Cassina Lopéz B, Regan MS, Randall EC, Clark AR, Cox CR, Agar NYR. Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLIMSI) Using Cerium(IV) Oxide. Anal Chem. 2019 May 21;91(10):6800-6807. doi: 10.1021/acs.analchem.9b00894. Epub 2019 May 8. PubMed PMID: 31025851.
  • Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP. In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe. ACS Chem Biol. 2019 Jun 21;14(6):1097-1101. doi: 10.1021/acschembio.9b00069. Epub 2019 May 13. PubMed PMID: 31059217.
  • Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677. doi: 10.1073/pnas.1904099116. Epub 2019 Jun 10. PubMed PMID: 31182571; PubMed Central PMCID: PMC6601261.
  • Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi:10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed PMID: 30799286; PubMed Central PMCID: PMC6506399.
  • Tye BW, Commins N, Ryazanova LV, Wühr M, Springer M, Pincus D, Churchman LS. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Elife. 2019 Mar 7;8. pii: e43002. doi: 10.7554/eLife.43002. PubMed PMID: 30843788; PubMed Central PMCID: PMC6453566.
  • Adam Y, Kim JJ, Lou S, Zhao Y, Xie ME, Brinks D, Wu H, Mostajo-Radji MA, Kheifets S, Parot V, Chettih S, Williams KJ, Gmeiner B, Farhi SL, Madisen L, Buchanan EK, Kinsella I, Zhou D, Paninski L, Harvey CD, Zeng H, Arlotta P, Campbell RE, Cohen AE. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics. Nature. 2019 May;569(7756):413-417. doi: 10.1038/s41586-019-1166-7. Epub 2019 May 1. PubMed PMID: 31043747; PubMed Central PMCID: PMC6613938.
  • Farhi SL, Parot VJ, Grama A, Yamagata M, Abdelfattah AS, Adam Y, Lou S, Kim JJ, Campbell RE, Cox DD, Cohen AE. Wide-Area All-Optical Neurophysiology in Acute Brain Slices. J Neurosci. 2019 Jun 19;39(25):4889-4908. doi:10.1523/JNEUROSCI.0168-19.2019. Epub 2019 Apr 5. PubMed PMID: 30952812.
  • Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL. 6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. Cell Chem Biol. 2019 Jun 4. pii: S2451-9456(19)30175-8. doi: 10.1016/j.chembiol.2019.05.006. [Epub ahead of print] PubMed PMID: 31204288.
  • Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, Sellers WR. The landscape of cancer cell line metabolism. Nat Med. 2019 May;25(5):850-860. doi: 10.1038/s41591-019-0404-8. Epub 2019 May 8. PubMed PMID: 31068703; PubMed Central PMCID: PMC6629041.
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  • Velilla J, Marchetti MM, Toth-Petroczy A, Grosgogeat C, Bennett AH, Carmichael N, Estrella E, Darras BT, Frank NY, Krier J, Gaudet R, Gupta VA. Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis. Neurol Genet. 2019 Mar 7;5(2):e312. doi:10.1212/NXG.0000000000000312. eCollection 2019 Apr. PubMed PMID: 31041394; PubMed Central PMCID: PMC6454305.
  • Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A. Conservation of the structure and function of  bacterial tryptophan synthases. IUCrJ. 2019 May 29;6(Pt 4):649-664. doi:10.1107/S2052252519005955. eCollection 2019 Jul 1. PubMed PMID: 31316809; PubMed Central PMCID: PMC6608616.
  • Valencia AM, Kadoch C. Chromatin regulatory mechanisms and therapeutic opportunities in cancer. Nat Cell Biol. 2019 Feb;21(2):152-161. doi: 10.1038/s41556-018-0258-1. Epub 2019 Jan 2. Review. PubMed PMID: 30602726.
  • Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D. Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature. 2019 Mar;567(7749):550-553. doi: 10.1038/s41586-019-1039-0. Epub 2019 Mar 20. PubMed PMID: 30894747; PubMed Central PMCID: PMC6629255.
  • Vinyard ME, Su C, Siegenfeld AP, Waterbury AL, Freedy AM, Gosavi PM, Park Y, Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019 May;15(5):529-539. doi: 10.1038/s41589-019-0263-0. Epub 2019 Apr 15. PubMed PMID: 30992567.
  • Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Publisher Correction: Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019 May;15(5):550. doi: 10.1038/s41589-019-0254-1. PubMed PMID: 30858597.
  • Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019 Apr;15(4):419-426. doi: 10.1038/s41589-019-0229-2. Epub 2019 Feb 11. Erratum in:  Nat Chem Biol. 2019 Mar 11;:. PubMed PMID: 30742124; PubMed Central PMCID: PMC6430648.
  • Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Continuous evolution of base editors with expanded target compatibility and improved activity. Nat Biotechnol. 2019 Jul 22. doi: 10.1038/s41587-019-0193-0. [Epub ahead of print] PubMed PMID: 31332326.
  • Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nat Commun. 2019 Apr 26;10(1):1937. doi: 10.1038/s41467-019-09987-0. PubMed PMID: 31028261; PubMed Central PMCID: PMC6486577.
  • Roth TB, Woolston BM, Stephanopoulos G, Liu DR. Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2. ACS Synth Biol. 2019 Apr 19;8(4):796-806. doi: 10.1021/acssynbio.8b00481. Epub 2019 Mar 20. PubMed PMID: 30856338; PubMed Central PMCID: PMC6479731.
  • Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0168-1. PubMed PMID: 31182863.
  • Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019 Jun;37(6):626-631. doi: 10.1038/s41587-019-0134-y. Epub 2019 May 20. Erratum in: Nat Biotechnol. 2019 Jun 10;:. PubMed PMID: 31110355; PubMed Central PMCID: PMC6551276.
  • Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 Mar 26;201(8). pii: e00577-18. doi: 10.1128/JB.00577-18. Print 2019 Apr 15. PubMed PMID: 30692177; PubMed Central
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  • Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK. Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. Cell Chem Biol. 2019 May 16;26(5):765-777.e3. doi: 10.1016/j.chembiol.2019.02.018. Epub 2019 Apr 4. PubMed PMID: 30956147; PubMed Central PMCID: PMC6526536.
  • Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi:
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  • Magin RS, Doherty LM, Buhrlage SJ. Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme. Cell Chem Biol. 2019 Feb 21;26(2):153-155. doi: 10.1016/j.chembiol.2019.02.006. PubMed PMID: 30794786.
  • Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S. Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection. J Am Chem Soc. 2019 Aug 2. doi: 10.1021/jacs.9b06061. [Epub ahead of print] PubMed PMID: 31373491.
  • Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. Mol Cell. 2019 Jul 25;75(2):357-371.e7. doi: 10.1016/j.molcel.2019.05.019. Epub 2019 Jun 18. PubMed PMID: 31227231.
  • Fagbami L, Deik AA, Singh K, Santos SA, Herman JD, Bopp SE, Lukens AK, Clish CB, Wirth DF, Mazitschek R. The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling. ACS Infect Dis. 2019 Apr 12;5(4):515-520. doi: 10.1021/acsinfecdis.8b00363. Epub 2019 Feb 21. PubMed PMID: 30773881.
  • Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 May;20(5):664. doi: 10.1038/s41590-019-0361-x. PubMed PMID: 30846880.
  • Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 Mar;20(3):276-287. doi: 10.1038/s41590-018-0303-z. Epub 2019 Jan 28. Erratum in: Nat Immunol. 2019 Mar 7;:. PubMed PMID: 30692621; PubMed Central PMCID: PMC6450391.
  • Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23. PubMed PMID: 30674671; PubMed Central PMCID: PMC6369754.

2018

  • Clark AR, Calligaris D, Regan MS, Pomeranz Krummel D, Agar JN, Kallay L, MacDonald T, Schniederjan M, Santagata S, Pomeroy SL, Agar NYR, Sengupta S. Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. J Neurooncol. 2018 Nov;140(2):269-279. doi: 10.1007/s11060-018-2978-2. Epub 2018 Aug 20. PubMed PMID: 30128689; PubMed Central PMCID: PMC6244779.
  • Basu SS, Randall EC, Regan MS, Lopez BGC, Clark AR, Schmitt ND, Agar JN, Dillon DA, Agar NYR. In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture. Anal Chem. 2018 Apr 17;90(8):4987-4991. doi: 10.1021/acs.analchem.8b00530. Epub 2018 Apr 2. PubMed PMID: 29608279; PubMed Central PMCID: PMC6196362.
  • Koppel N, Bisanz JE, Pandelia ME, Turnbaugh PJ, Balskus EP. Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins. Elife. 2018 May 15;7. pii: e33953. doi: 10.7554/eLife.33953. PubMed PMID: 29761785; PubMed Central PMCID: PMC5953540.
  • Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. PubMed PMID: 30102854; PubMed Central PMCID: PMC6333101.
  • Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018 Nov 15;7. pii: e41305. doi: 10.7554/eLife.41305. PubMed PMID: 30431433; PubMed Central PMCID: PMC6277197.
  • Michel BC, D'Avino AR, Cassel SH, Mashtalir N, McKenzie ZM, McBride MJ, Valencia AM, Zhou Q, Bocker M, Soares LMM, Pan J, Remillard DI, Lareau CA, Zullow HJ, Fortoul N, Gray NS, Bradner JE, Chan HM, Kadoch C. A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation. Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5. PubMed PMID: 30397315.
  • Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155. doi: 10.1084/jem.20171066. Epub 2018 Jul 25. PubMed PMID: 30045945; PubMed Central PMCID: PMC6080915.
  • Cohen AE, Farhi SL. Sculpting light to reveal brain function. Nat Neurosci. 2018 Jun;21(6):776-778. doi: 10.1038/s41593-018-0158-5. PubMed PMID: 29802389.
  • Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255. doi:10.1021/acs.jmedchem.7b01655. Epub 2018 Apr 24. PubMed PMID: 29660984; PubMed Central PMCID: PMC6294449.
  • Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. doi:10.1016/j.chembiol.2018.01.013. Epub 2018 Feb 22. PubMed PMID: 29478907; PubMed Central PMCID: PMC5973797.
  • Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545. doi: 10.1021/acsmedchemlett.8b00011. eCollection 2018 Jun 14. PubMed PMID: 29937979; PubMed Central PMCID: PMC6004574.
  • Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory. ACS Chem Neurosci. 2018 Sep 19;9(9):2262-2273. doi: 10.1021/acschemneuro.8b00116. Epub 2018 Jun 22. PubMed PMID: 29932631.
  • Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018 Jul;20(7):745-754. doi: 10.1038/s41556-018-0124-1. Epub 2018 Jun 27. Review. PubMed PMID: 29950572; PubMed Central PMCID: PMC6541229.
  • Wellington S, Hung DT. The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infect Dis. 2018 May 11;4(5):696-714. doi: 10.1021/acsinfecdis.7b00255. Epub 2018 Feb 15. PubMed PMID: 29412643.
  • Levi SM, Li Q, Rötheli AR, Jacobsen EN. Catalytic activation of glycosyl phosphates for stereoselective coupling reactions. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):35-39. doi: 10.1073/pnas.1811186116. Epub 2018 Dec 17. PubMed PMID: 30559190; PubMed Central PMCID: PMC6320501.
  • Mashtalir N, D'Avino AR, Michel BC, Luo J, Pan J, Otto JE, Zullow HJ, McKenzie ZM, Kubiak RL, St Pierre R, Valencia AM, Poynter SJ, Cassel SH, Ranish JA, Kadoch C. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Cell. 2018 Nov 15;175(5):1272-1288.e20. doi:
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  • Michel BC, D'Avino AR, Cassel SH, Mashtalir N, McKenzie ZM, McBride MJ, Valencia AM, Zhou Q, Bocker M, Soares LMM, Pan J, Remillard DI, Lareau CA, Zullow HJ, Fortoul N, Gray NS, Bradner JE, Chan HM, Kadoch C. A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation. Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5. PubMed PMID: 30397315.
  • McBride MJ, Pulice JL, Beird HC, Ingram DR, D'Avino AR, Shern JF, Charville GW, Hornick JL, Nakayama RT, Garcia-Rivera EM, Araujo DM, Wang WL, Tsai JW, Yeagley M, Wagner AJ, Futreal PA, Khan J, Lazar AJ, Kadoch C. The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma. Cancer Cell. 2018 Jun 11;33(6):1128-1141.e7. doi: 10.1016/j.ccell.2018.05.002. Epub 2018 May 31. PubMed PMID: 29861296.
  • McBride MJ, Kadoch C. Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities. J Pathol. 2018 Apr;244(5):638-649. doi: 10.1002/path.5042. Epub 2018 Mar 6. Review. PubMed PMID: 29359803.
  • Sherman DJ, Xie R, Taylor RJ, George AH, Okuda S, Foster PJ, Needleman DJ, Kahne D. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Science. 2018 Feb 16;359(6377):798-801. doi: 10.1126/science.aar1886. PubMed PMID: 29449493; PubMed Central PMCID: PMC5858563.
  • Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2359-2364. doi: 10.1073/pnas.1711727115. Epub 2018 Feb 20. PubMed PMID: 29463713; PubMed Central PMCID: PMC5877925.
  • Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D. Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport. J Am Chem Soc. 2018 Jun 6;140(22):6749-6753. doi: 10.1021/jacs.8b02283. Epub 2018 May 16. PubMed PMID: 29746111; PubMed Central PMCID: PMC5990483.
  • Schaefer K, Owens TW, Kahne D, Walker S. Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus. J Am Chem Soc. 2018 Feb 21;140(7):2442-2445. doi: 10.1021/jacs.7b13551. Epub 2018 Feb 9. PubMed PMID: 29402087; PubMed Central PMCID: PMC5870139.
  • Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. PubMed PMID: 29813047; PubMed Central PMCID: PMC6126947.
  • Wang T, Badran AH, Huang TP, Liu DR. Continuous directed evolution of proteins with improved soluble expression. Nat Chem Biol. 2018 Oct;14(10):972-980. doi: 10.1038/s41589-018-0121-5. Epub 2018 Aug 20. PubMed PMID: 30127387; PubMed Central PMCID: PMC6143403.
  • Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2018 Jul;559(7714):E8. doi: 10.1038/s41586-018-0070-x. PubMed PMID: 29720650.
  • Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. 2018 Oct 17;29(10):3245-3249. doi: 10.1021/acs.bioconjchem.8b00563. Epub 2018 Sep 21. PubMed PMID: 30231608; PubMed Central PMCID: PMC6429940.
  • Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. PubMed PMID: 29813047; PubMed Central PMCID: PMC6126947.
  • Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R,  Mitchison TJ. Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14. PubMed PMID: 30429313; PubMed Central PMCID: PMC6275538.
  • Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4. PubMed PMID: 30082792; PubMed Central PMCID: PMC6078993.
  • Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA. Mammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 Sep 4;19(17):1827-1833. doi: 10.1002/cbic.201800214. Epub 2018 Jul 26. PubMed PMID: 29931794; PubMed Central PMCID: PMC6156985.
  • Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018 Sep 25;24(13):3393-3403.e5. doi: 10.1016/j.celrep.2018.08.089. PubMed PMID: 30257201; PubMed Central PMCID: PMC6365304.
  • Wood BM, Santa Maria JP Jr, Matano LM, Vickery CR, Walker S. A partial reconstitution implicates DltD in catalyzing lipoteichoic acid d-alanylation. J Biol Chem. 2018 Nov 16;293(46):17985-17996. doi: 10.1074/jbc.RA118.004561. Epub 2018 Sep 20. PubMed PMID: 30237166; PubMed Central PMCID: PMC6240853.
  • Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix. J Am Chem Soc. 2018 Mar 14;140(10):3510-3513. doi: 10.1021/jacs.7b13546. Epub 2018 Mar 5. PubMed PMID: 29485866; PubMed Central PMCID: PMC5937710.
  • Santiago M, Lee W, Fayad AA, Coe KA, Rajagopal M, Do T, Hennessen F, Srisuknimit V, Müller R, Meredith TC, Walker S. Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic. Nat Chem Biol. 2018 Jun;14(6):601-608. doi: 10.1038/s41589-018-0041-4. Epub 2018 Apr 16. PubMed PMID: 29662210; PubMed Central PMCID: PMC5964011.
  • Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix. J Am Chem Soc. 2018 Mar 14;140(10):3510-3513. doi: 10.1021/jacs.7b13546. Epub 2018 Mar 5. PubMed PMID: 29485866; PubMed Central PMCID: PMC5937710.
  • Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. doi: 10.1021/jacs.8b07328. Epub 2018 Oct 4. PubMed PMID: 30285435; PubMed Central PMCID: PMC6261342.
  • Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10845-10852. doi:10.1073/pnas.1810524115. Epub 2018 Oct 2. PubMed PMID: 30279182; PubMed Central PMCID: PMC6205419.

2017

  • Koppel N, Maini Rekdal V, Balskus EP. Chemical transformation of xenobiotics by the human gut microbiota. Science. 2017 Jun 23;356(6344). pii: eaag2770. doi:10.1126/science.aag2770. Review. PubMed PMID: 28642381; PubMed Central PMCID: PMC5534341.
  • Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. doi: 10.1002/anie.201611281. Epub 2017 Apr 18. PubMed PMID: 28418626; PubMed Central PMCID: PMC5967236.
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  • Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3. PubMed PMID: 28671682.
  • Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C. SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat Genet. 2017 Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25. PubMed PMID: 28945250; PubMed Central PMCID: PMC5803080.
  • Otto JE, Kadoch C. A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver. Cancer Cell. 2017 Nov 13;32(5):542-543. doi: 10.1016/j.ccell.2017.10.014. PubMed PMID: 29136498.
  • Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C. SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat Genet. 2017 Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25. PubMed PMID: 28945250; PubMed Central PMCID: PMC5803080.
  • May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport. J Am Chem Soc. 2017 Dec 6;139(48):17221-17224. doi: 10.1021/jacs.7b07736. Epub 2017 Nov 22. PubMed PMID: 29135241; PubMed Central PMCID: PMC5735422.
  • Komor AC, Badran AH, Liu DR. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018 Feb 16;13(2):383-388. doi: 10.1021/acschembio.7b00710. Epub 2017 Oct 9. Review. PubMed PMID: 28957631; PubMed Central PMCID: PMC5891729.
  • Chan AI, McGregor LM, Jain T, Liu DR. Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195. doi: 10.1021/jacs.7b04880. Epub 2017 Jul 20. PubMed PMID: 28689404; PubMed Central PMCID: PMC5575935.
  • Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017 Aug 30;3(8):eaao4774. doi: 10.1126/sciadv.aao4774. eCollection 2017 Aug. PubMed PMID: 28875174; PubMed Central PMCID: PMC5576876.
  • Woolston BM, Roth T, Kohale I, Liu DR, Stephanopoulos G. Development of a formaldehyde biosensor with application to synthetic methylotrophy. Biotechnol Bioeng. 2018 Jan;115(1):206-215. doi: 10.1002/bit.26455. Epub 2017 Nov 3. PubMed PMID: 28921510; PubMed Central PMCID: PMC5699943.
  • Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5. PubMed PMID: 28678785; PubMed Central PMCID: PMC5667900.
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  • Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Rep. 2017 Mar 14;18(11):2664-2675. doi: 10.1016/j.celrep.2017.02.044. PubMed PMID: 28297670.
  • Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ. Inhibition of USP10 induces degradation of oncogenic FLT3. Nat Chem Biol. 2017 Dec;13(12):1207-1215. doi: 10.1038/nchembio.2486. Epub 2017 Oct 2. PubMed PMID: 28967922; PubMed Central PMCID: PMC6314479.
  • Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure. 2018 Jan 2;26(1):153-160.e4. doi: 10.1016/j.str.2017.11.016. Epub 2017 Dec 21. PubMed PMID: 29276033; PubMed Central PMCID: PMC5947960.
  • Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139(31):10597-10600. doi: 10.1021/jacs.7b04726. Epub 2017 Jul 28. PubMed PMID: 28727445; PubMed Central PMCID: PMC5699463.
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  • Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nat Chem Biol. 2017 Apr;13(4):396-401. doi: 10.1038/nchembio.2302. Epub 2017 Feb 6. PubMed PMID: 28166208; PubMed Central PMCID: PMC5362317.
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2016

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  • Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N. Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7894-9. doi:10.1073/pnas.1605015113. Epub 2016 Jun 27. PubMed PMID: 27354530; PubMed Central PMCID: PMC4948368.
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  • Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Sci Transl Med. 2016 Aug 10;8(351):351ra106. doi: 10.1126/scitranslmed.aaf7551. PubMed PMID: 27510902; PubMed Central PMCID: PMC5784409.
  • Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chem Biol. 2016 Jun 23;23(6):666-77. doi: 10.1016/j.chembiol.2016.05.011. Epub 2016 Jun 16. PubMed PMID: 27321573; PubMed Central PMCID: PMC4920728.
  • Simpson BW, Owens TW, Orabella MJ, Davis RM, May JM, Trauger SA, Kahne D, Ruiz N. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. MBio. 2016 Oct 18;7(5). pii: e01729-16. doi: 10.1128/mBio.01729-16. PubMed PMID: 27795402; PubMed Central PMCID: PMC5082905.
  • Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R. Compounds that select against the tetracycline-resistance efflux pump. Nat Chem Biol. 2016 Nov;12(11):902-904. doi: 10.1038/nchembio.2176. Epub 2016 Sep 19. PubMed PMID: 27642863; PubMed Central PMCID: PMC5069154.
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  • Badran AH, Guzov VM, Huai Q, Kemp MM, Vishwanath P, Kain W, Nance AM, Evdokimov A, Moshiri F, Turner KH, Wang P, Malvar T, Liu DR. Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance. Nature. 2016 May 5;533(7601):58-63. doi: 10.1038/nature17938. Epub 2016 Apr 27. PubMed PMID: 27120167; PubMed Central PMCID: PMC4865400.
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  • Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7. PubMed PMID: 27602946; PubMed Central PMCID: PMC5515376.
  • Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7. PubMed PMID: 26953159; PubMed Central PMCID: PMC4878416.
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  • Matano LM, Morris HG, Wood BM, Meredith TC, Walker S. Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening. Bioorg Med Chem. 2016 Dec 15;24(24):6307-6314. doi: 10.1016/j.bmc.2016.08.003. Epub 2016 Aug 16. PubMed PMID: 27594549; PubMed Central PMCID: PMC5180449.
  • Levine ZG, Walker S. The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells? Annu Rev Biochem. 2016 Jun 2;85:631-57. doi: 10.1146/annurev-biochem-060713-035344. Review. PubMed PMID: 27294441.
  • Rajagopal M, Martin MJ, Santiago M, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S. Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. MBio. 2016 Aug 16;7(4). pii: e00950-16. doi: 10.1128/mBio.00950-16. PubMed PMID: 27531908; PubMed Central PMCID: PMC4992970.
  • Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13. PubMed PMID: 27746017; PubMed Central PMCID: PMC5089849.
  • Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11. PubMed PMID: 27069117; PubMed Central PMCID: PMC4854733.
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2015

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  • Chien MP, Werley CA, Farhi SL, Cohen AE. Photostick: a method for selective isolation of target cells from culture. Chem Sci. 2015 Mar;6(3):1701-1705. PubMed PMID: 25705368; PubMed Central PMCID: PMC4334133.
  • Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-606. doi:10.1021/acs.jmedchem.5b00710. Epub 2015 Aug 18. PubMed PMID: 26258521; PubMed Central PMCID: PMC4777322.
  • Wivagg CN, Wellington S, Gomez JE, Hung DT. Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis. ACS Infect Dis. 2016 Feb 12;2(2):104-10. doi:
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  • Badran AH, Liu DR. Development of potent in vivo mutagenesis plasmids with broad mutational spectra. Nat Commun. 2015 Oct 7;6:8425. doi: 10.1038/ncomms9425. PubMed PMID: 26443021; PubMed Central PMCID: PMC4633624.
  • Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nat Methods. 2015 Oct;12(10):939-42. doi: 10.1038/nmeth.3515. Epub 2015 Aug 10. PubMed PMID: 26258293; PubMed Central PMCID: PMC4589463.
  • Chan AI, McGregor LM, Liu DR. Novel selection methods for DNA-encoded chemical libraries. Curr Opin Chem Biol. 2015 Jun;26:55-61. doi: 10.1016/j.cbpa.2015.02.010. Epub 2015 Feb 24. Review. PubMed PMID: 25723146; PubMed Central PMCID: PMC4475454.
  • Brancucci NM, Goldowitz I, Buchholz K, Werling K, Marti M. An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development. Nat Protoc. 2015 Aug;10(8):1131-42. doi: 10.1038/nprot.2015.072. Epub 2015 Jul 2. PubMed PMID: 26134953; PubMed Central PMCID: PMC4581880.
  • Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ; LSFC Consortium, Vachon L, Morin C, Laprise C, Rioux JD, Mootha VK, Des Rosiers C. A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome. Cell Rep. 2015 Nov 3;13(5):981-9. doi: 10.1016/j.celrep.2015.09.054. Epub 2015 Oct 22. PubMed PMID: 26565911; PubMed Central PMCID: PMC4644511.
  • Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16;137(49):15378-81. doi: 10.1021/jacs.5b10596. Epub 2015 Dec 3. PubMed PMID: 26583201; PubMed Central PMCID: PMC4697197.
  • Pasquina L, Santa Maria JP Jr, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol. 2016 Jan;12(1):40-5. doi: 10.1038/nchembio.1967. Epub 2015 Nov 30. PubMed PMID: 26619249; PubMed Central PMCID: PMC4684722.
  • Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC. A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics. 2015 Mar 29;16:252. doi: 10.1186/s12864-015-1361-3. PubMed PMID: 25888466; PubMed Central PMCID: PMC4389836.
  • Pasquina L, Santa Maria JP Jr, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol. 2016 Jan;12(1):40-5. doi: 10.1038/nchembio.1967. Epub 2015 Nov 30. PubMed PMID: 26619249; PubMed Central PMCID: PMC4684722.
  • Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC. A new platform for ultra-high density Staphylococcus aureus transposon libraries. BMC Genomics. 2015 Mar 29;16:252. doi: 10.1186/s12864-015-1361-3. PubMed PMID: 25888466; PubMed Central PMCID: PMC4389836.
  • Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. PubMed PMID: 25751766; PubMed Central PMCID: PMC4475500.
  • Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. PubMed PMID: 25751766; PubMed Central PMCID: PMC4475500.
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  • Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments. J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14. PubMed PMID:  26468282; PubMed Central PMCID: PMC4705927.
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2014

  • Sörensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G, Eggert US. The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol. 2012 Sep 21;7(9):1502-8. PMCID: PMC3448819.
  • Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7. doi:10.1073/pnas.1302257110. Epub 2013 May 28. PubMed PMID: 23716698; PubMed Central PMCID: PMC3683768.
  • Lee S, Braun CR, Bird GH, Walensky LD. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014;544:25-48. doi: 10.1016/B978-0-12-417158-9.00002-9. PubMed PMID: 24974285.
  • Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic BAK. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E986-95. doi: 10.1073/pnas.1214313110. Epub 2013 Feb 12. PubMed PMID: 23404709; PubMed Central PMCID: PMC3600461.
  • Carlson, J. C.; Badran, A. H.; Guggiana-Nilo, D. A.; Liu, D. R. (2014) Negative selection and stringency modulation in phage-assisted continuous evolution. Nature Chemical Biology, 10, 216-222 PMCID: PMC3977541
  • Freinkman E, Okuda S, Ruiz N, Kahne D. Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry. 2012 Jun 19;51(24):4800-6. doi: 10.1021/bi300592c. Epub 2012 Jun 8. PubMed PMID: 22668317; PubMed Central PMCID: PMC3426634.
  • Okuda S, Freinkman E, Kahne D. Cytoplasmic ATP hydrolysis powers transport of  lipopolysaccharide across the periplasm in E. coli. Science. 2012 Nov 30;338(6111):1214-7. doi: 10.1126/science.1228984. Epub 2012 Nov 8. PubMed PMID: 23138981; PubMed Central PMCID: PMC3552488.
  • Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28;494(7438):480-3. doi: 10.1038/nature11897. PubMed PMID: 23446419; PubMed Central PMCID: PMC3730528.
  • McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc. 2014 Feb 26;136(8):3264-70. doi: 10.1021/ja412934t. Epub 2014 Feb 17. PubMed PMID: 24495225; PubMed Central PMCID: PMC3985698.
  • Santa Maria JP Jr, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12510-5. doi: 10.1073/pnas.1404099111. Epub 2014 Aug 7. PubMed PMID:25104751; PubMed Central PMCID: PMC4151746.
  • McKeown MR, Bradner JE. Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med. 2014 Oct 1;4(10). pii: a014266. doi: 10.1101/cshperspect.a014266. PubMed PMID: 25274755.
  • McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. PubMed PMID: 25314271; PubMed Central PMCID: PMC4234447.
  • Strittmatter, L., Li, Y., Nakatsuka, N.J., Calvo, S.E., Grabarek, Z., Mootha, V.K., 2014, “CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity,” Hum. Mol. Genet., 23(9):2313-23. PMCID 24334609
  • Tan JL, Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011;105:493-516. doi: 10.1016/B978-0-12-381320-6.00021-7. PubMed PMID: 21951544.
  • Nguyen PA,  Groen AC,  Loose M,  Ishihara K,  Wühr M,  Field CM,  Mitchison TJ., Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science. 2014 Oct 10;346(6206):244-7. doi: 10.1126/science.1256773. PubMed PMID: 25301629.
  • Ankarklev J, Brancucci NM, Goldowitz I, Mantel PY, Marti M. Sex: how malaria parasites get turned on. Curr Biol. 2014 May 5;24(9):R368-70. doi:
    10.1016/j.cub.2014.03.046. PubMed PMID: 24801188.
  • Badran AH, Liu DR. In vivo continuous directed evolution. Curr Opin Chem Biol. 2014 Nov 7;24C:1-10. doi: 10.1016/j.cbpa.2014.09.040. [Epub ahead of print] Review. PubMed PMID: 25461718.
  • Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schroder, G. F., Fitzgerald, K. A., Wu, H. & Egelman, E. H. (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Cell. 156, 1193-206. PMID: 24630722
  • Lu, A., Kabaleeswaran, V., Fu, T., Magupalli, V. G. & Wu, H. (2014) Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions, Journal of molecular biology. 426, 1420-7. PMID: 24406744
  • Federation, A.J., Bradner, J.E., Meissner, A., 2014, “The use of small molecules in somatic-cell reprogramming.” Trends in cell biology, 24:179-87. PMID: 24183602
  • Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc. 2014 Oct 22;136(42):14678-81. doi:10.1021/ja508147s. Epub 2014 Oct 10. PubMed PMID: 25291014; PubMed Central PMCID:PMC4210121.
  • Wang F, Chan C, Weir NR, Denic V. The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature. 2014 Aug
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  • Sourav Banerjee, S., Buhrlage, S.J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A.R., Alessi, D.R., Gray, N.S., 2014, "Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases," Biochem. J. 457, 215-225. PMCID: PMC3969223
  • Meier, B.C. and Wagner, B.K., 2014, "Inhibition of HDAC3 as a Strategy for Developing Novel Diabetes Therapeutics," Epigenomics, 6(2): 209-214, PMID: 24811789.
  • Hochbaum, D.R., Zhao, Y., Farhi, S.L., Klapoetke, N., Werley, C.A., Kapoor, V., Kralj, J.M., Maclaurin, D., Smedemark-Margulies, N., Saulnier, J.L., Boulting, G.L., Straub, C., Cho, Y.K., Melkonian, M., Wong, G.K., Harrison, D.J., Murthy, V.N., Sabatini, B.L., Boyden, E.S., Campbell, R.E., and Cohen, A.E., 2014, "All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins," Nature Methods, Vol 11, 825-33. PMCID: PMC4117813

2013

  • Lajoie MJ, Kosuri S, Mosberg JA, Gregg CJ, Zhang D, Church GM. Probing the limits of genetic recoding in essential genes. Science. 2013 Oct 18;342(6156):361-3. doi: 10.1126/science.1241460. PubMed PMID: 24136967.

  • Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically recoded organisms expand biological functions. Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459. PubMed PMID: 24136966.

  • Ling J, Daoud R, Lajoie MJ, Church GM, Söll D, Lang BF. Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucleic Acids Res. 2014 Jan;42(1):499-508. doi: 10.1093/nar/gkt842. Epub 2013 Sep 17. PubMed PMID:24049072; PubMed Central PMCID: PMC3874161.

  • Pasquina LW, Santa Maria JP, Walker S. Teichoic acid biosynthesis as an antibiotic target. Curr Opin Microbiol. 2013 Oct;16(5):531-7. doi:10.1016/j.mib.2013.06.014. Epub 2013 Jul 31. Review. PubMed PMID: 23916223; PubMed Central PMCID: PMC3834221.

  • Brown S, Santa Maria JP Jr, Walker S. Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol. 2013;67:313-36. doi:10.1146/annurev-micro-092412-155620. Review. PubMed PMID: 24024634; PubMed Central PMCID: PMC3883102

  • Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

  • Mantel, P. Y., *A. N. Hoang, *I. Goldowitz, *D. Potashnikova, B. Hamza, I. A. Vorobjev, I. Ghiran, M. Toner, D. Irimia, R. Ivanov, N. Barteneva, M. Marti (2013). Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host and Microbe 13, 521-534. PMID: 23684304

  • Kawate, T., Iwase, N., Shimizu, M., Stanley, S.A., Wellington, S., Kazyanskaya, E., Hung, D.T. (2013). Synthesis and Structure-Activity Relationships of Phenyl-substituted Coumarins with anti-tubercular
    activity that target FadD32, Bioorganic & Medicinal Chemistry Letters 23(22), 6052–6059. doi:10.1016/j.bmcl.2013.09.035. Epub 2013 Sept 19. Pubmed PMID:24103299

2012

  • Yuan Yuan, Qiu Wang, Joshiawa Paulk, Stefan Kubicek, Melissa M. Kemp, Drew J. Adams, Alykhan F. Shamji, Bridget K. Wagner, and Stuart L. Schreiber. 1. A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma. ACS Chemical Biology 2012 7 (7), 1152-1157. PMCID:PMC3401036
  • Carr PA*, Wang HH*, Sterling B*, Isaacs FJ, Lajoie MJ, Xu G, Church GM, Jacobson JM (2012) Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. NAR; doi: 10.1093/nar/gks455
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mitchison T, Wühr M, Nguyen PA, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken). 2012 Oct;69(10):738-50. doi:
  • Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Hong Lim JC, Pei-Ying Sim C, Chu YS; WCR participants, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. The first World Cell Race. Curr Biol. 2012 Sep 11;22(17):R673-5. 
  • Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17; 150(4):673-684
  • Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Curr Biol. 2012 May 22;22(10):R409-11. 
  • Leoni V*, Strittmatter L*, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab. 2012 Mar;105(3):463-71 (* indicates equal contribution)
  • Weigert O, Lane AA, Bird L, Kopp N, Chapuy B, van Bodegom D, Toms AV, Marubayashi S, Christie AL, McKeown M, Paranal RM, Bradner JE, Yoda A, Gaul C, Vangrevelinghe E, Romanet V, Murakami M, Tiedt R, Ebel N, Evrot E, De Pover A, Régnier CH, Erdmann D, Hofmann F, Eck MJ, Sallan SE, Levine RL, Kung AL, Baffert F, Radimerski T, Weinstock DM. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012 Feb 13; 208(2):259-73
  • Nakamura H, Hamer HA, Sirasani G, Balskus EP. Cylindrocyclophane Biosynthesis Involves Functionalization of an Unactivated Carbon Center.JACS 2012 ASAP.
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751

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