Marie Hollenhorst

Marie Hollenhorst

Assistant Professor of Medicine, Harvard Medical School
Associate Physician, Brigham and Women's Hospital, Division of Hematology
Enrollment Year - 2007
Walsh Lab - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Advisor: Chris Walsh
Dissertation Title: Biosynthesis and Bioloigcal Activity of the Dapdiamide Antibiotics.

Hollenhorst Lab
77 Ave Louis Pasteur
BHIM739
Boston, MA 02115

Email: mhollenhorst@bwh.harvard.edu 

Website: hollenhorst.bwh.harvard.edu
Lab Size: Between 5-10

Summary

The Hollenhorst laboratory studies glycoproteins that play critical roles in hemostasis and thrombosis (bleeding and clotting). Platelets and coagulation factors are heavily coated in glycans (carbohydrate polymers) which are essential for healthy function of the hemostatic system. We are interested in understanding how these glycans regulate the structure and function of hemostatic glycoproteins, and modulate the anti-platelet immune response. We welcome students who want to perform cutting-edge research using the tools of chemical biology to dissect platelet and coagulation factor glycobiology. Our ultimate goal is to improve the lives of patients with bleeding and thrombotic disorders.

Publications

Tiemeyer KH, Kuter DJ, Cairo CW, Hollenhorst MA. New insights into the glycobiology of immune thrombocytopenia. Current Opinion in Hematology. 2023 Jul 28. DOI: 10.1097/MOH.0000000000000781PMID: 37526945.

Hollenhorst MA, Tiemeyer KT, Mahoney KE, Aoki K, Ishihara M, Lowery SC, Rangel-Angarita V, Bertozzi CR, Malaker SA. Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation. Journal of Thrombosis and Hemostasis. 2023; 21, 995-1009.https://doi.org/10.1016/j.jtha.2023.01.009 

Jajosky RP, Wu SC, Zheng L, Jajosky AN, Jajosky PG, Josephson CD, Hollenhorst MA, Sackstein R, Cunnings RD, Arthur CM, Stowell SR. ABO blood group antigens and differential glycan expression; perspective on the evolution of common human enzyme deficiencies. iScience, 2022; 26, 105798, https://doi.org/10.1016/j.isci.2022.105798 

Swenson E, Wong LK, Jhaveri P, Weng Y, Kappagoda S, Pandey S, Pritchard A, Rogers A, Ruoss S, Subramanian A, Shan H, Hollenhorst MA, Active surveillance of serious adverse events following transfusion of COVID-19 convalescent plasma. Transfusion. 2022; 62, 28-36. https://doi.org/10.1111/trf.16711 

Hollenhorst MA, Al-Samkari H, Kuter DJ, Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance. Blood Advances. 2019; 3, 3515-21. https://doi.org/10.1182/bloodadvances.2019000400 

Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT, The nonribosomal peptide synthetase enzyme DdaD tethers fumaramoyl-L-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Journal of the American Chemical Society. 2010; 132, 15773-81.  https://doi.org/10.1021/ja1072367