Kanarek

Naama Kanarek

Assistant Professor of Pathology

Department of Pathology

Boston Children Hospital / Harvard Medical School

Enders 1116.2

300 Longwood Ave

Boston, MA 02115

Tel: (617) 355-7433

Email: Naama.Kanarek@childrens.harvard.edu

Website: https://www.kanareklab.com/

Lab Size: 5-10

Summary: 

The Kanarek Laboratory is interested in folate metabolism. It is surprising that this essential vitamin, so famous for its key role in development, hematopoiesis and cancer progression, is still a mystery when it comes to its cellular and whole-body sensing and homeostasis.

The Kanarek lab applies genetic perturbations, biochemical assays, molecular biology, functional genomic screens, and metabolite profiling by mass spectrometry in cell-culture systems and in vivo to study basic folate biology including folate metabolism, folate-related signal transduction, the oncogenic role of folate and folate homeostasis in normal physiology and pathological conditions.

Publications:

https://www.kanareklab.com/publications

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR.

Copper induces cell death by targeting lipoylated TCA cycle proteins.

Science 2022 Mar 18;375(6586):1254-1261. 

​Petrova B, Warren A, Vital NY, Culhane AJ, . Maynard AG, Wong A, Kanarek N*.

Redox metabolism measurement in mammalian cells and tissues by LC-MS. 

Metabolites 11(5): 313.

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Petrova B and Kanarek N*.

Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement.

J Nutrition. 2020 Oct 1;150 (Supplement_1) :2580S-2587S. doi: 10.1093/jn/nxaa132. PMID 33000153 

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Kanarek N*, Petrova B, and Sabatini DM.

Dietary modifications for enhanced cancer therapy. 

Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25. Review PMID: 32214253 

Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM

Histidine catabolism is a major determinant of methotrexate sensitivity.

Nature 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11.