Xin Zhou
Assistant Professor of BCMP

Dana-Farber Cancer Institute
360 Longwood Ave.
Longwood Center 
Boston, MA 02215
Email: xin_zhou1@dfci.harvard.edu

Website: ZHOU LAB (zhou-lab.org)

Lab Size: Between 15-20


The Zhou Laboratory employs a protein engineering-centric approach to manipulate cancer signaling machinery and immunity. We incorporate dynamic, functional proteins into innovative molecular technology and biomedicine designs with the ultimate goal of better understanding and reversing diseases.

Our research spans three interrelated directions:

·         Designing and evolving novel protein sensors and switches

·         Engineering cell signaling pathways to build molecular recorders and editors

·         Developing new biotherapeutic modalities



Elledge, S.*, Zhou, X.*, Byrnes, J., Martinko, A., Lui, I., Pance, K., Lim, S., Glasgow, J., Glasgow, A., Turcios, K., Iyer, N., Torres, L., Peluso, M., Henrich, T., Wang, T., Tato, C., Leung, K., Greenhouse, B., Wells, J.# Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nature Biotechnology 2021, 39: 928–935.

Zhou, X., Bracken, C., Zhang, K., Zhou, J., Mou, Y., Wang, L., Cheng, Y., Leung, K., Wells, J.# Targeting phosphotyrosine in native proteins with conditional, bi-specific antibody traps. J. Am. Chem. Soc. 2020. 142(41), 17703–17713.

Zhou, X., Fan, L., Li, P., Shen, K., Lin, M.#, Optical control of cell signaling by single-chain photoswitchable kinases. Science 2017, 355: 836–842.

Zhou, X., Pan, M., Lin, M.#, Investigating neuronal function with optically controllable proteins. Frontiers in Molecular Neuroscience 2015, 8: 37.

Zhou, X., Chung, H., Lam, A., Lin, M.#, Optical control of protein activity by fluorescent protein domains. Science 2012. 338: 810–814.