The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by the collective activity of...
The laboratory is primarily focused on developing and applying single-molecule methods to better understand the molecular dynamics of the multi-protein complexes that are involved in genome maintenance. Areas of current interest include:
Regulation of...
Our laboratory studies how ubiquitin‐dependent protein degradation controls cell cycle progression in normal and cancer cells. We integrate biochemical, cell biological, and chemical approaches to study the ubiquitin-proteasome pathway. We are interested...
