Our research focuses on exploring novel therapeutic strategies for cancer through a multi-disciplinary approach, including synthetic chemistry, medicinal chemistry, chemical biology, computational biology, and biology. We study gene regulatory pathways...
Mutations in cancer cells lead to malfunctioning control of gene expression - a dysregulated epigenome. The Ott Laboratory is dedicated to discovering the control factors of the epigenome that are essential for cancer cell survival. Discovery of these...
Our central goal is to develop novel chemical biology and functional genomic approaches to illuminate molecular mechanisms in epigenetics and gene regulation, while exploring the promise of chromatin regulators as therapeutic targets for cancer.
The Liau...
Chemical neurobiology of neuropsychiatric disorders: We use chemical biology along with molecular and cell biology approaches to understand how the nervous system functions in health and disease. We are particularly interested in the molecular mechanisms...
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
Research in the Blacklow laboratory is centered around the molecular logic of normal and pathogenic Notch signaling. Activating mutations in human Notch1 are found in more than half of human T-cell leukemias, and a key goal of current research is...
Our research involves the chemical biology of protein post-translational modifcations (PTMs) in the context of signaling, epigenetics, and cancer. We develop and apply chemical approaches including protein semisynthesis and small molecule probes to the...
