The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
Mutations in cancer cells lead to malfunctioning control of gene expression - a dysregulated epigenome. The Ott Laboratory is dedicated to discovering the control factors of the epigenome that are essential for cancer cell survival. Discovery of these...
Our central goal is to develop novel chemical biology and functional genomic approaches to illuminate molecular mechanisms in epigenetics and gene regulation, while exploring the promise of chromatin regulators as therapeutic targets for cancer.
The Liau...
Our laboratory is centered in understanding the structure and function of ATP-dependent chromatin remodeling complexes, with an emphasis on their role in human cancer. Over the past several years, we have developed extensive expertise in the application...
Chemical neurobiology of neuropsychiatric disorders: We use chemical biology along with molecular and cell biology approaches to understand how the nervous system functions in health and disease. We are particularly interested in the molecular mechanisms...
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
Research in the Blacklow laboratory is centered around the molecular logic of normal and pathogenic Notch signaling. Activating mutations in human Notch1 are found in more than half of human T-cell leukemias, and a key goal of current research is...
Genome editing may provide a lasting treatment for many genetic disorders by correcting disease mutations or making compensatory changes to the genome. We develop platforms using genome editing tools to investigate cellular mechanisms of neurodegeneration...
