The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
The Walker Group has expertise in studying bacterial cell wall biosynthesis and its inhibition. We have developed chemical approaches to study the membrane-linked steps of peptidoglycan and teichoic acid biosynthesis, and have made fundamental...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
The laboratory is primarily focused on developing and applying single-molecule methods to better understand the molecular dynamics of the multi-protein complexes that are involved in genome maintenance. Areas of current interest include:
Regulation of...
My laboratory uses methods in molecular and structural biology (X-ray crystallography, Cryo-electron microscopy, and Nuclear Magnetic Resonance) to characterize the protein synthesis machinery of parasites, such as the ones causing Leishmaniasis and...
The Kahne Lab has had a longstanding interest in the problem of antibiotic resistance. Bacteria eventually develop resistance all classes of antibiotics but, for Gram-negative bacteria the problem is especially serious. Unlike Gram-positive bacteria, they...
We seek to decode the molecular language of host-microbiome communication using systematic CRISPR technologies and an interdisciplinary set of focused approaches.
Resistance to antibiotics is arguably one of the most important challenges facing human health in the coming decades. It can arise through the acquisition of new genes or through mutations in existing genes that block antimicrobial action. Resistance is...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...
