For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by the collective activity of...
The laboratory is primarily focused on developing and applying single-molecule methods to better understand the molecular dynamics of the multi-protein complexes that are involved in genome maintenance. Areas of current interest include:
Regulation of...
Research in the Blacklow laboratory is centered around the molecular logic of normal and pathogenic Notch signaling. Activating mutations in human Notch1 are found in more than half of human T-cell leukemias, and a key goal of current research is...
