The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
Plants synthesize an immense number of bioactive small molecules that help them to thrive in hostile environments. These molecules serve a multitude of functions for the plant, such as defense against pests and pathogens, nutrient acquisition, and...
The Kahne Lab has had a longstanding interest in the problem of antibiotic resistance. Bacteria eventually develop resistance all classes of antibiotics but, for Gram-negative bacteria the problem is especially serious. Unlike Gram-positive bacteria, they...
Chemical neurobiology of neuropsychiatric disorders: We use chemical biology along with molecular and cell biology approaches to understand how the nervous system functions in health and disease. We are particularly interested in the molecular mechanisms...
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...
The focus of our research is the discovery of new enzymatic and non-enzymatic chemistry in living systems. We are particularly inspired by the breadth of reactions used by microorganisms in both primary and secondary metabolism. Microbes are Nature’s...
