The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by the collective activity of...
My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology...
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...
The laboratory is primarily focused on developing and applying single-molecule methods to better understand the molecular dynamics of the multi-protein complexes that are involved in genome maintenance. Areas of current interest include:
Regulation of...
Structural biology of ion channels and transporters: The Gaudet lab uses a combination of structural, biophysical and biochemical approaches to study signaling and transport through biological membranes. Particular systems of interest are ABC transporters...
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
My lab develops physical tools to study molecules, cells and organisms. We apply these tools to make new measurements. The work in the lab combines molecular and cell biology, instrumentation development, and extensive computation and numerical...
Research in the Blacklow laboratory is centered around the molecular logic of normal and pathogenic Notch signaling. Activating mutations in human Notch1 are found in more than half of human T-cell leukemias, and a key goal of current research is...
