Tim Springer
Latham Family Professor of Biological Chemistry and Molecular Pharmacology
My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease. A common theme throughout our research is how force interacts with protein conformational change to activate integrins, von Willebrand factor, proteins of the transforming growth factor-beta family, and adhesins on malaria sporozoites.