The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...
Our central goal is to develop novel chemical biology and functional genomic approaches to illuminate molecular mechanisms in epigenetics and gene regulation, while exploring the promise of chromatin regulators as therapeutic targets for cancer.
The Liau...
Hung is working at the interface of chemical biology, infectious disease, and genetic/genomics to better understand the host-bacterial pathogen interaction and explore new paradigms for how to intervene on infection therapeutically. She has been...
Structural biology of ion channels and transporters: The Gaudet lab uses a combination of structural, biophysical and biochemical approaches to study signaling and transport through biological membranes. Particular systems of interest are ABC transporters...
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
Cancer cells display remarkable plasticity allowing them to adapt to ever changing environments. A key feature of this plasticity is their ability to rewire core metabolic networks to provide a steady source of energy and building blocks needed for rapid...
Genome editing may provide a lasting treatment for many genetic disorders by correcting disease mutations or making compensatory changes to the genome. We develop platforms using genome editing tools to investigate cellular mechanisms of neurodegeneration...
The research aims to develop and implement biochemical classifications to enable surgeons and oncologists to tailor treatment from the time of surgery, and allow personalized cancer care using molecular imaging with mass spectrometry. Molecular...
