The Walker Group has expertise in studying bacterial cell wall biosynthesis and its inhibition. We have developed chemical approaches to study the membrane-linked steps of peptidoglycan and teichoic acid biosynthesis, and have made fundamental...
The Hedgehog signaling pathway has critical roles in the embryonic development, in maintaining stem cells and in human cancer. We use biochemistry, cell and chemical biology to understand how vertebrate cells send and interpret Hedgehog signals. We also...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
The Kahne Lab has had a longstanding interest in the problem of antibiotic resistance. Bacteria eventually develop resistance all classes of antibiotics but, for Gram-negative bacteria the problem is especially serious. Unlike Gram-positive bacteria, they...
We seek to decode the molecular language of host-microbiome communication using systematic CRISPR technologies and an interdisciplinary set of focused approaches.
The Hollenhorst laboratory studies glycoproteins that play critical roles in hemostasis and thrombosis (bleeding and clotting). Platelets and coagulation factors are heavily coated in glycans (carbohydrate polymers) which are essential for healthy...
The Flynn lab develops chemical tools to study the interface of RNA biology and glycobiology in the context of cell state transitions and cell-cell communication.
Determining how cells grow and divide is a fundamental goal of biology. However, these processes remain poorly understood even in the simplest of cells. In bacteria, growth and division are intimately linked to the construction of the cell wall layer that...
The focus of our research is the discovery of new enzymatic and non-enzymatic chemistry in living systems. We are particularly inspired by the breadth of reactions used by microorganisms in both primary and secondary metabolism. Microbes are Nature’s...
