Antibodies, checkpoint inhibitors, and CAR-T cells have all been successful in leveraging the immune system against disease, but these treatment strategies still have limitations. Our Laboratory employs a protein engineering-centric approach to probe and...
The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
Immunotherapy has transformed cancer treatment, yet many patients still do not achieve effective responses. In our lab, we explore cancer immunology through a multidisciplinary approach that integrates chemical biology, protein engineering, molecular...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
Our lab uses experimental approaches at the intersection of chemical biology and stem cell biology in order to investigate cellular pathways relevant to neuropsychiatric disorders. We are interested in leveraging the power of small-molecule probes for the...
We seek to decode the molecular language of host-microbiome communication using systematic CRISPR technologies and an interdisciplinary set of focused approaches.
Hung is working at the interface of chemical biology, infectious disease, and genetic/genomics to better understand the host-bacterial pathogen interaction and explore new paradigms for how to intervene on infection therapeutically. She has been...
The Hollenhorst laboratory studies glycoproteins that play critical roles in hemostasis and thrombosis (bleeding and clotting). Platelets and coagulation factors are heavily coated in glycans (carbohydrate polymers) which are essential for healthy...
Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...
