Antibodies, checkpoint inhibitors, and CAR-T cells have all been successful in leveraging the immune system against disease, but these treatment strategies still have limitations. Our Laboratory employs a protein engineering-centric approach to probe and...
Many biological processes are governed by chemical signals relayed through protein networks. These small molecule signals can inhibit, enhance, or impart new functions to proteins through direct associations to regulatory hotspots on a protein that drive...
The Walker Group has expertise in studying bacterial cell wall biosynthesis and its inhibition. We have developed chemical approaches to study the membrane-linked steps of peptidoglycan and teichoic acid biosynthesis, and have made fundamental...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by the collective activity of...
My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology...
The Silver Lab works at the interface between systems and synthetic biology to design and build biological systems in both mammalian and prokaryotic cells. Some current projects include analysis of cells that remember past events, cell-based computation...
The Hedgehog signaling pathway has critical roles in the embryonic development, in maintaining stem cells and in human cancer. We use biochemistry, cell and chemical biology to understand how vertebrate cells send and interpret Hedgehog signals. We also...
Immunotherapy has transformed cancer treatment, yet many patients still do not achieve effective responses. In our lab, we explore cancer immunology through a multidisciplinary approach that integrates chemical biology, protein engineering, molecular...
David R. Liu is the Richard Merkin Professor and director of the Merkin Institute of Transformative Technologies in Healthcare, vice-chair of the faculty at the Broad Institute of MIT and Harvard, the Thomas Dudley Cabot Professor of the Natural Sciences...
