Antibodies, checkpoint inhibitors, and CAR-T cells have all been successful in leveraging the immune system against disease, but these treatment strategies still have limitations. Our Laboratory employs a protein engineering-centric approach to probe and...
The laboratory focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology...
The Hedgehog signaling pathway has critical roles in the embryonic development, in maintaining stem cells and in human cancer. We use biochemistry, cell and chemical biology to understand how vertebrate cells send and interpret Hedgehog signals. We also...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
MOLECULAR BASIS OF INSTINCTIVE ANIMAL BEHAVIOR
Neural circuits that generate perception and control behavior are poorly understood at a molecular level. We are interested in understanding how the brain processes external sensory and internal homeostatic...
Our research aims to elucidate the molecular basis of signaling using protein engineering and biophysical methods including X-ray crystallography.
G protein-coupled receptors (GPCRs) are cell-surface receptors that regulate neurotransmission...
Our lab uses experimental approaches at the intersection of chemical biology and stem cell biology in order to investigate cellular pathways relevant to neuropsychiatric disorders. We are interested in leveraging the power of small-molecule probes for the...
We seek to decode the molecular language of host-microbiome communication using systematic CRISPR technologies and an interdisciplinary set of focused approaches.
